货号：MABE216

品牌：Merck Millipore

规格：EA

目录价：￥3708.00

市场价格：￥3151.80

会员价格：￥2966.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nuclear SET domain containing protein 2 Antibody, clone 9A6 | MABE216 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: N-terminus View All» Molecular Weight: ~71 kDa observed. Seven isoforms are known to exist in different, known cell lines. View All» Epitope: This antibody recognizes the N-terminus of Nuclear SET domain containing protein 2. This antibody recognizes isoform 1 (152 kDa), isoform 3 (71 kDa), isoform 4 (66 kDa), and isoform 5 (69 kDa). However, it does not recognize isoform 2 (81 kDa), which lacks the respective epitope containing N-terminus region (Huddlebusch, H. R., et al. (2011). Clin Cancer Res. 17(9):2919-2933.). View All» Immunogen: GST-tagged recombinant protein corresponding to human Nuclear SET domain containing protein 2. View All» Clone: 9A6.B3 View All» Isotype: IgG1κ View All» Background Information: Also known as Multiple myelomas SET (MMSET) and Wolf-Hirschhorn syndrome candidate 1 protein (WHSC1), Nuclear SET domain containing protein 2 (NSD2) is a histone lysine methyltransferase that is deregulated in a subgroup of multiple myelomas. NSD proteins have been described to serve as oncogenes; however, little is known about their targets in transcriptional repression or activation. NSD2 is overexpressed in multiple myelomas via translocation between the NSD2 locus on chromosome 4 and the immunoglobulin locus on chromosome 14. NSD2 is under the regulatory control of this immunoglobulin locus. Further research is required to elucidate its roles and mechanisms in cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A representative lot from an independent laboratory detected Nuclear SET domain containing protein 2 in human myeloma tissue (Huddlebusch, H. R., et al. (2011). Clin Cancer Res. 17(9):2919-2933.). View All» Control: COLO-587 cell lysate View All» Quality Assurance: Evaluated by Western Blot in COLO-587 cell lysate.Western Blot Analysis: A 1:500 dilution from a representative lot detected Nuclear SET domain containing protein 2 in 200 µg of COLO-587 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O96028 View All» Entrez Gene Number: NP_579889 View All» Gene Symbol:

• WHSC1

• MMSET

• NSD2

• TRX5
  View All» Alternate Names:
  • Probable histone-lysine N-methyltransferase NSD2

  • Multiple myeloma SET domain-containing protein

  • Nuclear SET domain-containing protein 2

  • Protein trithorax-5

  • Wolf-Hirschhorn syndrome candidate 1 protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Product Name: Anti-Nuclear SET domain containing protein 2, clone 9A6 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
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