货号：MABE22

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NO66 Antibody, clone 8A7-G10 | MABE22 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NO66. View All» Molecular Weight: ~ 67 kDa Observed View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to mouse NO66. View All» Clone: 8A7-G10 View All» Isotype: IgG1κ View All» Background Information: NO66 is a lysine-specific demethylase that removes methyl groups from histone H3 at lysine 4 and and lysine 36. This enzyme has been shown to more readily demethylate trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 Lys4 (H3K4me1) consistent with its role in modulating the histone code. This protein is a highly conserved, constitutive nucleolar component that shows a dual localization pattern with strong enrichment in the granular part of nucleoli and in distinct nucleoplasmic entities. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NO66 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JJF3 View All» Entrez Gene Number: NP_076122 View All» Gene Symbol:

• NO66

• hsNO66
  View All» Alternate Names:
  • chromosome 14 open reading frame 169

  • MYC-associated protein with JmjC domain

  • Nucleolar protein 66

  • Lysine-specific demethylase NO66
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Histone demethylase that specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. CATALYTIC ACTIVITY: Protein N6,N(6)-dimethyl-L-lysine + 2-oxoglutarate + O2 = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO2. Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O2 = protein L-lysine + succinate + formaldehyde + CO2.COFACTOR: Binds 1 Fe2+ ion per subunit.SUBUNIT STRUCTURE: Interacts with SP7/OSX; the interaction is direct. SUBCELLULAR LOCATION: Nucleus › nucleolus By similarity. Nucleus › nucleoplasm TISSUE SPECIFICTY: Present in developing bones (at protein level). Widely but not ubiquitously expressed.SEQUENCE SIMILARITIES: Belongs to the MINA53/NO66 family. NO66 subfamily.Contains 1 JmjC domain. View All» Product Name: Anti-NO66, clone 8A7-G10 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-132940.htm
    © Merck Millipore代理MABE22 Anti-NO66, clone 8A7-G10，产品报价联系微信jinshanbio