货号：MABE229

品牌：Merck Millipore

规格：100UL

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Cdk1 (Thr14, Tyr15), clone CP3.2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Cdk1 phosphorylated at Thr14 and phosphorylated at Tyr15. View All» Molecular Weight: ~34 kDa observed. An uncharacterized band may be observed at ~62 kDa in some cell lysates. View All» Epitope: Phosphorylated Thr14 and phosphorylated Tyr15 View All» Immunogen: Linear peptide corresponding to human Cdk1 phosphorylated at Thr14 and phosphorylated at Tyr15. View All» Clone: CP3.2 View All» Isotype: IgG1κ View All» Background Information: Cyclin dependent kinase 1 (Cdk1) regulates cell cycle progression. It is active as a heterodimeric complex with cyclins. Cdk1 associates with cyclin A at the end of S phase and targets proteins such as p53, BARD1, and BRCA2 involved in cell cycle progression, and others involved in DNA replication. At the end of the G2 phase, Cdk1 associates with cyclin B1 and B2 to phosphorylate multiple protein targets required for transition from G2 to M phase, and progression through M phase. Cdk1 itself undergoes phosphorylation at Thr14 and Tyr15 by PKMYT1, which prevents nuclear translocation of Cdk1. Cdk1 is also phosphorylated at Tyr15 by WEE1/2 which inhibits both Cdk1 activity and transition from G2 to M phase. Conversely, dephosphorylation of Thr14 and Tyr15 by CDC25A/B activates Cdk1 and triggers mitosis. Cdk1 may also regulate epigenetic gene silencing through phosphorylation of EZH2 and maintenance of histone H3 lysine 27 trimethylation, which has been implicated in cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: UV treated and untreated HeLa cell lysates View All» Quality Assurance: Evaluated by Western Blot in UV treated and untreated HeLa cell lysates.Western Blot Analysis: A 1:1,000 dilution from a representative lot detected phospho-Cdk1 (Thr14, Tyr15) in UV treated HeLa cell lysates. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P06493 View All» Entrez Gene Number: NP_001777 View All» Gene Symbol:

• CDK1

• CDC2

• CDC28A

• CDKN1

• P34CDC2
  View All» Alternate Names:
  • Cyclin-dependent kinase 1

  • CDK1

  • Cell division control protein 2 homolog

  • Cell division protein kinase 1

  • p34 protein kinase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Product Name: Anti-phospho-Cdk1 (Thr14, Tyr15), clone CP3.2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MABE229 Anti-phospho-Cdk1 (Thr14, Tyr15)Antibody, clone CP3.2;store at +2℃ to +8℃，产品报价联系微信jinshanbio