货号：MABE241

品牌：Merck Millipore

规格：100UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12 | MABE241 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H3 dimethylated and phosphorylated at Lys9/27 and Ser10/28. View All» Molecular Weight: ~17 kDa observed View All» Epitope: Dimethylated and phosphorylated at Lys9/27 and Ser10/28. View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human Histone H3 dimethylated and phosphorylated at Lys9/27 and Ser10/28. View All» Clone: 51TA-2H1 View All» Isotype: IgG1κ View All» Background Information: Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli, including phosphorylation on serine and threonine residues and methylation on lysine residues. PTMs produce configural changes in histone proteins that may induce nucleosome remodeling and expose or hide DNA sequences from transcriptional complexes. Methylation occurs on histone H3 at lysine 4, 9, 27, 36, and 79 residues. Previous studies have reported that methylation of H3 lysine 9 provides a binding site for heterochromatin adaptor proteins (HP1) which are involved in the formation of heterochromatin and gene repression. Conversely,deacetylation of histone H3 lysine 9 is associated with gene-activating events. Often, it is the pattern of different modifications on several histone residues that alter chromatin, rather than modification of single residues. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Western Blot Analysis: A representative lot was used by an independent laboratory in KCl whole-cell extract. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)Dot Blot Analysis: A representative lot was used by an independent laboratory in unmodified and modified Histone H3 peptides. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in NIH/3T3 cells. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse testis tissue. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.)Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HeLa cells. (Eberlin, A., et al. (2008). Molecular and Cellular Biology. 28(5):1739–1754.) View All» Control: Untreated and etoposide acid extract treated HeLa cell lysates. View All» Quality Assurance: Evaluated by Western Blot in untreated and etoposide acid extract treated HeLa cell lysates.Western Blot Analysis: A 1:5,000 dilution of this antibody detected Histone H3 on 10 µg of untreated and etoposide acid extract treated HeLa cell lysates. View All» Purification Method: Unpurified View All» Presentation: Mouse monoclonal IgG1κ ascites with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P68431 View All» Entrez Gene Number: NP_003520 View All» Gene Symbol:

• HIST1H3A

• H3FA

• HIST1H3B

• H3FL

• HIST1H3C

• H3FC

• HIST1H3D

• H3FB

• HIST1H3E

• HIST1H3F

• H3FI

• HIST1H3G

• H3FH

• HIST1H3H

• H3FK

• HIST1H3I

• H3FF

• HIST1H3J

• H3FJ
  View All» Alternate Names:
  • Histone H3.1

  • Histone H3/a

  • Histone H3/b

  • Histone H3/c

  • Histone H3/d

  • Histone H3/f

  • Histone H3/h

  • Histone H3/I

  • Histone H3/j

  • Histone H3/k

  • Histone H3/l
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Dot Blot

    • Immunocytochemistry

    • Immunoprecipitation

    • Immunohistochemistry
      View All» Product Name: Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28), clone 51TA-2H12 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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      © Merck Millipore代理MABE241 Anti-dimethyl-phospho Histone H3 (Lys9/27)/(Ser10/28) Antibody, clone 51TA-2H12;store at -20℃，产品报价联系微信jinshanbio