货号：MABE72

品牌：Merck Millipore

规格：

目录价：￥4013.00

市场价格：￥3411.05

会员价格：￥3210.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ash2 Antibody, clone 7E1 | MABE72 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 69 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human Ash2. View All» Clone: 7E1 View All» Isotype: IgG1κ View All» Background Information: Ash2 (absent, small or homeotic discs2) is a trithorax protein that as part of a complex trimethylates histone H3 at lysine 4. The resulting histone mark is associated with actively transcribed genes. Ash2 has been implicated as an oncoprotein and may function as a transcriptional regulator. .As a component of the Set1/Ash2 histone methyltransferase (HMT) complex, this complex specifically methylates lysine 4 of histone H3, unless the neighboring lysine 9 residue is already methylated. ASH2L is also a component of MLL-containing complexes. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. Ash2 has been shown to play a role in hematopoiesis and is associated with some special kinds of leukemia. The amount of ASH2L transcripts is extremely high in fetal liver, testis, and leukemia cell lines with erythroid and megakaryocytic potential View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Ash2 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UBL3 View All» Entrez Gene Number: NP_001098684 View All» Gene Symbol: ASH2L:ASH2L1 View All» Alternate Names: Set1/Ash2 histone methyltransferase complex subunit ASH2: ASH2-like protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunoprecipitation

• Immunohistochemistry
  View All» UniProt Summary: FUNCTION: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis. SUBUNIT STRUCTURE: Interacts with HCFC1. Core component of several methyltransferase-containing complexes including MLL1/MLL, ASCOM, MLL2/MLL3 and MLL3/MLL4. Each complex is at least composed of ASH2L, RBBP5, DPY30, WDR5, one or more specific histone methyltransferases (MLL, MLL2, MLL3 and MLL4), and the facultative components C16orf53/PA1, C17orf49, CHD8, E2F6, HCFC1, HCFC2, HSP70, IN80C, KDM6A, KIAA1267, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with DPY30 and RBBP5; the interaction is direct. SUBCELLULAR LOCATION: Nucleus Probable TISSUE SPECIFICITY: Ubiquitously expressed. Predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes. Ref.2SEQUENCE SIMILARITIES: Contains 1 B30.2/SPRY domain. View All» Product Name: Anti-Ash2, clone 7E1 View All» Concentration: 1.00 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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