货号：MABE98

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cdk5rap3 Antibody, clone 2H2 | MABE98 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~57 kDa observed View All» Immunogen: Recombinant Protein corresponding to human Cdk5rap3. View All» Clone: 2H2 View All» Isotype: IgG2aκ View All» Background Information: CDK5 regulatory subunit-associated protein 3 (Cdk5rap3) is a recently described regulator for Cdk5 activity through interaction with CDK5R1. It may also have a role in cell proliferation. Recent studies have shown Cdk5rap3 to have a crucial role in regulating apoptosis induced by genotoxic stress by interacting with the G2/M DNA damage checkpoint. Expression of Cdk5rap3 is considered ubiquitous, and has been observed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: U2OS cell lysate View All» Quality Assurance: Evaluated by Western Blot in U2OS cell lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected Cdk5rap3 in 10 µg of U2OS cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96JB5 View All» Entrez Gene Number: NP_788276 View All» Gene Symbol:

• Cdk5rap3

• IC53

• LZAP

• MST016

• HSF-27

• C53
  View All» Alternate Names:
  • CDK5 regulatory subunit associated protein 3

  • CDK5 regulatory subunit-associated protein 3

  • LXXLL/leucine-zipper-containing ARFbinding protein

  • ischemic heart CDK5 activator-binding protein C53

  • CDK5 activator-binding protein C53

  • Protein HSF-27
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). SUBUNIT STRUCTURE: Interacts with CDK5R1. This interaction is prevented by the association between CDK5R1 and CDK5RAP3 (By similarity). Interacts with the enteric adenovirus serotype 41 fiber protein.TISSUE SPECIFICTY: Ubiquitous. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform 3 is expressed in kidney, liver, skeletal muscle and placenta. PTM: Phosphorylated in vitro by CDK5 (By similarity).SEQUENCE SIMILARITIES: Belongs to the CDK5RAP3 family.SEQUENCE CAUTION: The sequence AAK69655.1 differs from that shown. Reason: Frameshift at position 410. View All» Product Name: Anti-Cdk5rap3, clone 2H2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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