货号：MABF22

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IL-1 Beta (C-term) Antibody, clone EP408Y, Rabbit | MABF22 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IL-1 Beta near the C-terminus. View All» Molecular Weight: ~17 kDa observed View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to human IL-1 Beta near the C-terminus. View All» Clone: EP408Y View All» Isotype: IgG View All» Background Information: Interleukin 1 beta (IL-1β) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn’s disease which makes IL1 beta an important target for this disease (4). View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Control: Recombinant protein, human IL-1 beta View All» Quality Assurance: Evaluated by Western Blot using recombinant human IL-1 beta.Western Blot Analysis: A 1:5,000 dilution of this antibody detected recombinant human IL-1 Beta.Note: Approximately 0.05 µg/lane [0.5 µg/200 µL] of recombinant protein was loaded on the membrane. View All» Purification Method: Unpurified View All» Presentation: Rabbit monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P01584 View All» Entrez Gene Number: NP_000567.1 View All» Gene Symbol:

• IL1F2

• IL-1 beta

• IL-1B

• IL-1

• OTTHUMP00000203693

• OTTHUMP00000203695

• OTTHUMP00000203694

• IL1-BETA
  View All» Alternate Names:
  • interleukin 1, beta

  • catabolin

  • pro-interleukin-1-beta

  • preinterleukin 1 beta

  • interleukin-1 beta

  • Catabolin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. View All» UniProt Summary: FUNCTION: Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. SUBUNIT STRUCTURE: Monomer.SUBCELLULAR LOCATION: Secreted. Note: The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.DOMAIN: The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.SEQUENCE SIMILARITIES: Belongs to the IL-1 family. View All» Product Name: Anti-IL-1 Beta (C-term), clone EP408Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-133022.htm
    © Merck Millipore代理MABF22 Anti-IL-1 Beta (C-terminus), clone EP408Y, Rabbit Monoclonal，产品报价联系微信jinshanbio