货号：MABF28

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PAR-3 Antibody, clone 8E8 | MABF28 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 40 kDa calculated View All» Immunogen: KLH-conjugated linear peptide corresponding to human PAR-3. View All» Clone: 8E8 View All» Isotype: IgG2bκ View All» Background Information: PAR-3 (also known as Coagulation factor II receptor-like 2, Thrombin receptor-like 2 or F2RL2) is an adapter protein involved in asymmetrical cell division and cell polarization processes. It seems to play a central role in the formation of epithelial tight junctions. Its association with PARD6B may prevent the interaction of PAR-3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PAR-3 complex links GTP bound Rho small GTPases to atypical protein kinase C proteins. PAR-3 interacts with PARD6A and PARD6B. Isoform 2, but not at least isoform 3 interacts with PRKCZ. PAR-3 interacts with PRCKI. PAR-3 forms part of a complex with PARD6A or PARD6B, PRKCI or PRKCZ and CDC42 or RAC1. PAR-3 interacts with F11R/JAM1. Antibodies against PAR-3 are present in sera from patients with cutaneous T cell lymphomas. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human based on 100% sequence homology. View All» Application Notes: Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Petrova, Y., et al. (2008). Centr Eur J Immunol. 33 (1):14-18.)Activity Assay Analysis (platelet aggregation): A previous lot was used by an independent laboratory in platelet aggregation assay. (Petrova, Y., et al. (2008). Centr Eur J Immunol. 33 (1):14-18.) View All» Control: Mouse platelets from washed whole blood (heparinized) View All» Quality Assurance: Evaluated by Flow Cytometry in mouse platelets from washed whole blood (heparinized).Flow Cytometry Analysis: 2 µg of this antibody detected PAR-3 in mouse platelets from washed whole blood (heparinized). View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00254 View All» Entrez Gene Number: NP_004092 View All» Gene Symbol:
  • PAR3

  • PARD3

  • ASIP

  • PHIP

  • SE2-5T2

  • PAR-3

  • SE2-5L16

  • PARD-3

  • PARD3A

  • PAR3A

  • PAR3alpha

  • PAR3-alpha

  • Bazooka

  • SE2-5LT1

  • F2RL2
    View All» Alternate Names:
    • Atypical PKC isotype-specific-interacting protein

    • CTCL tumor antigen se2-5

    • atypical PKC isotype-specific interacting protein

    • par-3 (partitioning defective 3, C.elegans) homolog

    • par-3 partitioning defective 3 homolog (C. elegans)

    • partitioning-defective protein 3 homolog, Coagulation factor II receptor-like 2, Thrombin receptor-like 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Enzyme Assay
        View All» Entrez Gene Summary: Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. SUBUNIT STRUCTURE: Interacts with INSC/inscuteable and probably GPSM2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICTY: Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut. PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.SEQUENCE CAUTION: The sequence CAD97628.1 differs from that shown. Reason: Frameshift at position 374. View All» Product Name: Anti-PAR-3, clone 8E8 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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