货号：MABF80

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-T-bet (TBX21) Antibody, clone 12E4.1 | MABF80 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~58 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to human TBX21. View All» Clone: 12E4.1 View All» Isotype: IgMκ View All» Background Information: TBX21 (T-box transcription factor, also known as T-Bet) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Studies in mouse show that TBX21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma. Expression of the human ortholog also correlates with IFN-G expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. TBX21 initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. Genetic variations in TBX21 are associated with susceptibility to asthma and nasal polyps. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Rat, Mouse, and Human. View All» Application Notes: Flow Cytometry Analysis: A 1:50 dilution from a representative lot detected T-bet (TBX21) in PC-12 cells.Western Blot Analysis: A 1:500 dilution from a previous lot detected T-bet (TBX21) in NIH/3T3 cell lysate. View All» Control: PC-12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC-12 cell lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected T-bet (TBX21) in PC-12 cell lysate.Optimal dilution to be determined by end user. View All» Purification Method: Purified by ion exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UL17 View All» Entrez Gene Number: NP_037483 View All» Gene Symbol:
  • TBX21

  • TBET

  • TBLYM
    View All» Alternate Names:
    • T-box transcription factor TBX21

    • T-box protein 21

    • T-cell-specific T-box transcription factor T-bet

    • Transcription factor TBLYM
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» Entrez Gene Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: T-cell specific. View All» Product Name: Anti-T-bet (TBX21), clone 12E4.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-133045.htm
        © Merck Millipore代理MABF80 Anti-T-bet/TBX21, clone 12E4.1，产品报价联系微信jinshanbio