货号：MABF81

品牌：Merck Millipore

规格：100Ug

目录价：￥4746.00

市场价格：￥4034.10

会员价格：￥3796.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ROR gamma T Antibody, clone 6F3.1 | MABF81 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~55 kDa observed. Two isoforms at ~55 kDa and ~58 kDa may be observed in some cell lysates. View All» Immunogen: GST-tagged recombinant protein corresponding to human ROR gamma T. View All» Clone: 6F3.1 View All» Isotype: IgG2aκ View All» Background Information: Retinoid-related orphan receptor-gamma t (RORγT) is one of two RORγ isoforms belonging to the nuclear hormone receptor family and contains a single nuclear receptor DNA-binding domain. RORγT is a negative regulator of TNFDF6/FASL expression and T-cell production of IL2. The upregulation of RORγT is a requirement for TH17 cell differentiation. Inhibition of RORγT is induced by TGF-β’s interaction with Foxp3. Expression is observed mainly in immature thymocytes, and, during fetal development, is found exclusively in lymphoid-inducer (LTi) cells. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected ROR gamma T in normal human liver tissues. View All» Control: T47D cell lysate View All» Quality Assurance: Evaluted in Western Blot in T47D cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected ROR gamma T in 10 µg of T47D cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51449 View All» Entrez Gene Number: NP_001001523 View All» Gene Symbol:

• RORC

• NR1F3

• RORG

• RZRG
  View All» Alternate Names:
  • Nuclear receptor ROR-gamma

  • Nuclear receptor RZR-gamma

  • Nuclear receptor subfamily 1 group F member 3

  • Retinoid-related orphan receptor-gamma
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4+ T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Isoform 1: widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2: Primarily expressed in immature thymocytes. View All» Product Name: Anti-ROR gamma T, clone 6F3.1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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