货号：MABF83

品牌：Merck Millipore

规格：

目录价：￥3109.00

市场价格：￥2642.65

会员价格：￥2487.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD2 Antibody, clone RPA-2.10 | MABF83 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 50 kDa calculated View All» Immunogen: Recombinant protein corresponding to human CD2. View All» Clone: RPA-2.10 View All» Isotype: IgG1κ View All» Background Information: CD2 is a 50 kDa single-chain type I transmembrane glycoprotein, originally defined as the sheep erythrocyte receptor. CD2 primarily binds CD58 on antigen-presenting cells and induces costimulatory signals in T cells. CD2 is one of the earliest T-cell lineage-restricted antigens to appear during T-cell differentiation, and it is expressed on most thymocytes, peripheral T cells and NK cells. Some B-cell non-Hodgkin lymphomas show aberrant expression of CD2, which may represent clonal expansion of CD2+ B lymphocytes that normally constitute a small fraction of peripheral B lymphocytes. Additionally, aberrant CD2 expression has been found in some acute myeloid leukemia almost exclusively restricted to the M3 and M4Eo variants. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Human PBMCs View All» Quality Assurance: Evaluated by Flow Cytometry in human PBMCs.Flow Cytometry Analysis: 0.1 µg/mL of this antibody detected CD2 in human PBMCs. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P06729 View All» Entrez Gene Number: NP_001758.2 View All» Gene Symbol:

• CD2

• SRBC
  View All» Alternate Names:
  • T-cell surface antigen CD2

  • Erythrocyte receptor

  • LFA-2

  • LFA-3 receptor

  • Rosette receptor

  • T-cell surface antigen T11/Leu-5
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. View All» UniProt Summary: FUNCTION: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.SUBUNIT STRUCTURE: Interacts with CD2AP. Interacts with PSTPIP1.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. View All» Product Name: Anti-CD2, clone RPA-2.10 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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