货号：MABN15

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rhodopsin Antibody, clone 4D2 | MABN15 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Rhodopsin at the N-terminus. View All» Molecular Weight: Expected at ~ 39 kDa. View All» Epitope: N-terminus View All» Immunogen: Rat rod outer segments corresponding to rat Rhodopsin at the N-terminus. View All» Clone: 4D2 View All» Isotype: IgG2bκ View All» Background Information: Rhodopsin is a multi-pass, G-protein-coupled membrane receptor protein belonging to the G-protein coupled receptor 1 family. Found within rod photoreceptor cells, rhodopsin is activated by light photons in order for the visual transduction cascade to initialize. Rhodopsin is necessary to the forming of images in low light and for the viability of photoreceptor cells after birth. Mutations in rhodopsin expression are the most widely known cause of the human disease retinitis pigmentosa (RP) resulting in gradual loss of vision. At present, there are over 100 known rhodopsin mutations. View All» Species Reactivity:

• Human

• Rat

• Fish

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and rat. Predicted to react with mouse based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A previous lot of this antibody detected Rhodopsin by WB in goldfish retina lysate, as reported by Knight K, et al.Immunocytochemistry: A previous lot of this antibody detected Rhodopsin by ICC in goldfish retina tissue, as reported by Knight K, et alImmunohistochemistry Analysis: 1:500 dilution of this antibody has been shown to detect Rhodopsin in human eye tissue.ELISA: Specificity of this antibody, from a different lot, was validated in a competitive ELISA, as reported by Laird D, et al. View All» Control: Rat eye tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat eye tissue.Immunohistochemistry Analysis: 1:500 dilution of this antibody detected Rhodopsin in rat eye tissue. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51489 View All» Entrez Gene Number: NP_254276 View All» Gene Symbol:
  • OPN2

  • RHO

  • RP4

  • CSNBAD

  • Opsin-2
    View All» Alternate Names:
    • rhodopsin

    • rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)

    • retinitis pigmentosa 4, autosomal dominant

    • opsin 2, rod pigment
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting

      • Immunocytochemistry

      • ELISA
        View All» Entrez Gene Summary: Visual pigment protein of rod photoreceptors involved in G-protein coupled receptor mediated signaling and phototransduction [RGD]. View All» UniProt Summary: FUNCTION: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal (By similarity).SUBUNIT STRUCTURE: Homodimer (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note: Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia (By similarity).TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates vision in dim light.PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.Contains one covalently linked retinal chromophore (By similarity).SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm View All» Product Name: Anti-Rhodopsin, clone 4D2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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