货号：MABN155

品牌：Merck Millipore

规格：200UL

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Sox1 Antibody, clone 2B3.3 | Cat. No. MABN155 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 36 kDa observed. Uncharacterized bands may appear at ~17 kDa and ~100 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Sox1. View All» Clone: 2B3.3 View All» Isotype: IgMκ View All» Background Information: SRY (Sex determining region Y)-box 1(Sox1), is a transcription factor that is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. Sox1 is also directly involved with sex determination of the Y chromosome. Binding of the Sox1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of Sox1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling. Sox1 may function as a switch in neuronal development. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design. View All» Control: Mouse neuronal stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse neuronal stem cell lysate.Western Blot Analysis: A 1:500 dilution of this antibody detected Sox1 in 200 µg of mouse neuronal stem cell lysate. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00570 View All» Entrez Gene Number: NP_005977 View All» Gene Symbol: SOX1 View All» Alternate Names: Transcription factor SOX-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Sox1, clone 2B3.3 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»