货号：MABN16

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Beclin-1 (C-term) Antibody, clone EPR1733Y, Rabbit | MABN16 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Beclin-1 near the C-terminus. View All» Molecular Weight: ~52 kDa observed View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to human Beclin-1 near the C-terminus. View All» Clone: EPR1733Y View All» Isotype: IgG View All» Background Information: The Beclin-1 (BECN1) gene encodes a 60 kDa coiled-coil protein that interacts with the prototypic apoptosis inhibitor Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, and in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity, tumorigenesis, and has been found to ameliorate the neurodegenerative pathology in α-Synuclein models of Parkinson's and lewy body diseases. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines and tissue, but is expressed ubiquitously at high levels in normal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear export signal motif raising the possibility that its autophagy and/or tumor suppressor function may require regulated, CRM1-dependent, nucleocytoplasmic transport (3). View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution from a previous lot detected Beclin-1 in human breast tissue.Immunocytochemistry Analysis: A 1:50 – 1:100 dilution from a previous lot detected Beclin-1 in HeLa cells.Immunoprecipitation Analysis: A 1:50 dilution from a previous lot detected Beclin-1 in IP. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: A 1:5,000 dilution of this antibody detected Beclin-1 in A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q14457 View All» Entrez Gene Number: NP_003757.1 View All» Gene Symbol:

• ATG6

• VPS30

• beclin1

• beclin-1

• GT197

• Protein GT197
  View All» Alternate Names:
  • beclin 1, autophagy related

  • beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)

  • Coiled-coil myosin-like BCL2-interacting protein

  • ATG6 autophagy related 6 homolog

  • beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)

  • beclin 1 (coiled-coil, moesin-like BCL2-interacting protein)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation

    • Immunocytochemistry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: Plays a central role in autophagy By similarity. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.SUBUNIT STRUCTURE: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with KIAA0831/Barkor. UVRAG and KIAA0831/Barkor form mutually exclusive complexes through direct competition for BECN1-binding. Interacts with BCL2 and BCL2L1. SUBCELLULAR LOCATION: Golgi apparatus › trans-Golgi network membrane; Peripheral membrane protein. Note: Interaction with KIAA0831/Barkor promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells By similarity. TISSUE SPECIFICITY: Ubiquitous.SEQUENCE SIMILARITIES: Belongs to the beclin family. View All» Product Name: Anti-Beclin-1 (C-term), clone EPR1733Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-133073.htm
      © Merck Millipore代理MABN16 Anti-Beclin-1 (C-terminus), clone EPR1733Y Rabbit Monoclonal，产品报价联系微信jinshanbio