货号：MABN238

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Glucagon Antibody, clone 13D11.33 | MABN238 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 21 kDa calculated View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human Glucagon. View All» Clone: 13D11.33 View All» Isotype: IgG2bκ View All» Background Information: Glucagon is a hormone that is proteolytically cleaved into at least eight different functional peptides. It is produced by pancreatic cells and it has binding sites in the brain, intestines, and liver, among other tissues. Glucagon is secreted in response to hypoglycemia. Through the combined activation of Gsα- and Gq-coupled transmembrane receptors and their downstream signaling pathways, glucagon stimulates the release of glucose from the liver into the bloodstream. One important mechanism underlying this process is the activation of protein kinase A (PKA). PKA signals result in increased transcription of phosphoenolpyruvate carboxykinase, which encodes the rate-limiting enzyme in the production of glucose from noncarbohydrate substrates. PKA signals may also increase the breakdown of glycogen, and suppress glycolysis. Glucagon may also engage in calcium-dependent signaling via PLC. The importance of glucagon in regulating glucose homeostasis, in conjunction with insulin, is underscored by findings that glucagon and glucagon receptor signaling are disrupted in type II diabetes. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:8,000 dilution from a representative lot detected Glucagon in normal rat pancreas tissue (For enhanced staining results, it is recommended to use a 10,000 dilution of this antibody.).ELISA Analysis: A representative lot detected Glucagon in ELISA.Luminex® Analysis: A representative lot detected Glucagon in Luminex Assay. View All» Control: Normal rat pancreas tissue View All» Quality Assurance: Evaluated by Immunofluorescence in normal rat pancreas tissue.Immunofluorescence Analysis: A 1:8,000 dilution of this antibody detected Glucagon in normal rat pancreas tissue. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P01275 View All» Entrez Gene Number: NP_002045 View All» Gene Symbol: GCG View All» Alternate Names:
  • 4030-01F

  • 4031-01F

  • AB932
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry (Paraffin)

    • Immunofluorescence

    • ELISA

    • Multiplexing
      View All» Product Name: Anti-Glucagon View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-133078.htm
      © Merck Millipore代理MABN238 Anti-Glucagon Antibody, clone 13D11.33;store at +2℃ to +8℃，产品报价联系微信jinshanbio