货号：MABN299

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CHL1 Antibody, clone BB13.13 | MABN299 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~165 kDa observed View All» Immunogen: Full length recombinant mouse CHL1 protein View All» Clone: BB13.13 View All» Isotype: IgG1κ View All» Background Information: Close homologue of L1 (CHL1) is a predominantly neural protein, which is highly expressed in the developing nervous system, particularly in neurons and glia of the cerebellum and spinal cord, and in Schwann cells of the peripheral nervous system. In addition to its roles in axon guidance, neuronal growth, and synaptic plasticity, CHL-1 may also regulate the differentiation of neural progenitor cells and the regeneration of nerve tissue. It belongs to the family of L1 adhesion proteins, and produces its effects through the interactions of its multiple domains, which include six immunoglobulin (Ig)-like domains; and over four fibronectin type III (FN)-like repeats. Mice lacking functional CHL-1 show abnormal axonal connectivity and display spatial and cognitive deficits. It has been suggested that the CHL-1 gene (CALL), which has been mapped to chromosome h3p26.1, is required for proper cognitive functioning in humans, and may contribute to “3p-syndrome.” View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Human. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected CHL1 on 10 µg of mouse p7 brain tissue lysate.Immunofluorescence Analysis: A representative lot was used by an independent laboratory in NIH/3T3 cells transfected with human CHL1. View All» Control: Mouse p1 spinal cord tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse p1 spinal cord tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected CHL1 on 10 µg of mouse p1 spinal cord tissue lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P70232 View All» Entrez Gene Number: NP_031723 View All» Gene Symbol:
  • Chl1

  • Call
    View All» Alternate Names:
    • Neural cell adhesion molecule L1-like protein

    • Cell adhesion molecule with homology to L1CAM

    • Chl1-like protein

    • Close homolog of L1

    • Processed neural cell adhesion molecule L1-like protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-CHL1, clone BB13.13 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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