货号：MABN35

品牌：Merck Millipore

规格：EA

目录价：￥3588.00

市场价格：￥3049.80

会员价格：￥2870.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Git1 Antibody, clone N39B/8 | MABN35 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 85 kDa observed View All» Immunogen: Recombinant protein corresponding to rat Git1. View All» Clone: N39B/8 View All» Isotype: IgG1κ View All» Background Information: ARF GTPase-activating protein GIT1 (Git1) is a multidomain protein belonging to the ARF family of small GTPases that is comprised of several protein interacting domains including: three Ankyrin repeats (ANKs), an Arf-Gap domain, a C-terminal GRK-binding domain, and a spa2 homology domain. Git1 is thought to have a role as a signaling pathway coordinator, functioning to regulate adhesion, cytoskeletal organization, and vesicle trafficking. It is also a component of several cytoplasmic complexes that contain ARHGEF6, PAK1, and PXN. In brain receptors, Git1 forms a complex with AMPA receptors, GRIP, and liprin-α, that is crucial to AMPA receptor targeting and the organization of synapses. Git1 expression is observed in a wide variety of tissues, with the most notable expression in the testis. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in adult rat hippocampus tissue. (James Trimmer, UC Davis/NIH NeuroMab Facility, Department of Neurobiology, Physiology and Behavior, UC Davis, Davis CA 95616-8519. neuromab@ucdavis.edu.) View All» Control: Rat brain membrane tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Git1 on 10 µg of rat brain membrane tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Z272 View All» Entrez Gene Number: NP_114002 View All» Gene Symbol:

• CAT1

• CAT-1

• GIT1

• ARF GAP GIT1
  View All» Alternate Names:
  • G protein-coupled receptor kinase interacting ArfGAP 1

  • G protein-coupled receptor kinase interactor 1

  • G protein-coupled receptor kinase-interactor 1

  • Cool-associated and tyrosine-phosphorylated protein 1

  • GRK-interacting protein 1

  • ARF GTPase-activating protein GIT1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Mediates beta2-adrenergic receptor endocytosis [RGD]. View All» UniProt Summary: FUNCTION: GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.SUBUNIT STRUCTURE: Interacts with SCRIB (By similarity). Interacts with G protein-coupled receptor kinases: ADRBK1/GRK2, PPFIA1 and PPFIA4, with ARHGEF6/alpha-PIX, with ARHGEF7/beta-PIX, with PXN/paxillin and with PTK2/FAK. Component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and PAK1. Interacts with TGFB1I1. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note: Cycles between at least 3 distinct intracellular compartments, including focal adhesions, cytoplasmic complexes and membrane protrusions. During cell migration, when cells detach, moves from the adhesions into the cytoplasmic complexes towards the leading edge, while, when cells adhere, it is found in vinculin-containing adhesions. Recruitment to adhesions may be mediated by active tyrosine-phosphorylated paxillin (By similarity).TISSUE SPECIFICTY: Expressed in numerous tissues, with highest levels in testis. PTM: Phosphorylated on tyrosine residues by PTK2 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).SEQUENCE SIMILARITIES: Contains 3 ANK repeats.Contains 1 Arf-GAP domain. View All» Product Name: Anti-Git1, clone N39B/8 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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