货号：MABN39

品牌：Merck Millipore

规格：EA

目录价：￥3828.00

市场价格：￥3253.80

会员价格：￥3062.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuroligin-3 Antibody, clone N110/29 | MABN39 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neuroligin-3 at the cytoplasmic domain. View All» Molecular Weight: ~ 90 kDa observed View All» Epitope: Cytoplasmic domain View All» Immunogen: Recombinant protein corresponding to rat Neuroligin-3 at the cytoplasmic domain. View All» Clone: N110/29 View All» Isotype: IgG1κ View All» Background Information: Neuroligins are Type I membrane proteins enriched in synaptic plasma membranes and clustered in synaptic clefts and postsynaptic densities. They have been characterized as neuronal cell surface proteins and are thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. They play a major role in the formation or maintenance of synaptic junctions. They are also thought to be involved in the specification of excitatory synapses. Neuroligins interact with beta-neurexins and this interaction is involved in the formation of functional synapses. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected Neuroligin-3 in rat brain (putamen area) and rat cerebellum tissue. View All» Control: Rat brain membrane tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Neuroligin-3 on 10 µg of rat brain membrane tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q62889 View All» Entrez Gene Number: NP_599163 View All» Gene Symbol:

• NLGN3

• HNL3

• NL3

• AUTSX1

• ASPGX1
  View All» Alternate Names:
  • Gliotactin homolog

  • Neuroligin-3

  • neuroligin 3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Neuronal cell surface protein that binds neurexins [RGD]. View All» UniProt Summary: FUNCTION: Neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins. May play a role in formation or maintenance of synaptic junctions. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system.SUBUNIT STRUCTURE: Interacts with neurexin 1-beta isoform 3/Beta 4B5A and isoform 4/Beta 4B5B. Interacts with neurexin 2-beta isoform 3/Beta 4B5A, isoform 4/Beta 4B5B, isoform 7/Beta 4B5A6 and isoform 8/Beta 4B5B6. Interacts with corresponding neurexin 3-beta isoforms. Probably interacts through its C-terminus with DLG4/PSD-95 third PDZ domain (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICTY: Expressed in brain, spinal chord and dorsal root ganglion. PTM: The N-terminus is blocked.SEQUENCE SIMILARITIES: Belongs to the type-B carboxylesterase/lipase family. View All» Product Name: Anti-Neuroligin-3, clone N110/29 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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