货号：MABN46

品牌：Merck Millipore

规格：100Ug

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~27 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human CLIC1.Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program. View All» Clone: CPTC-CLIC1 View All» Isotype: IgG2aκ View All» Background Information: Chloride intracellular channel protein 1 (CLIC1) is a part of the CLIC family of proteins. This family of proteins reconstitute in phospholipid vesicles and have been shown to have chloride channel action. CLIC1 may rotate between membrane-bound and soluble forms since it has been seen as a membrane protein and in the cytoplasm. When there is a lack of detergent, CLIC1 becomes membrane-bound and can act as an anion-selective channel. Recently, it has been shown that CLIC1 is required in angiogenesis and has a part in controlling integrin cell surface expression. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-CLIC1-2) View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected CLIC1 on 10 µg of human liver tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O00299 View All» Entrez Gene Number: NP_001279 View All» Gene Symbol:

• CLIC1

• G6

• NCC27

• p64CLCP

• hRNCC
  View All» Alternate Names:
  • chloride intracellular channel 1

  • Chloride channel ABP

  • RNCC protein

  • Nuclear chloride ion channel 27

  • nuclear chloride ion channel protein

  • Regulatory nuclear chloride ion channel protein

  • chloride intracellular channel protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. SUBUNIT STRUCTURE: Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9. SUBCELLULAR LOCATION: Nucleus. Nucleus membrane; Single-pass membrane protein Probable. Cytoplasm. Cell membrane; Single-pass membrane protein Probable. Note: Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. TISSUE SPECIFICTY: Expression is prominent in heart, placenta, liver, kidney and pancreas. DOMAIN: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion. PTM: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.MISCELLANEOUS: The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals.SEQUENCE SIMILARITIES: Belongs to the chloride channel CLIC family.Contains 1 GST C-terminal domain. View All» Product Name: Anti-Chloride intracellular channel protein (CLIC1), clone CPTC-CLIC1-1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MABN46 Anti-Chloride intracellular channel protein (CLIC1) Antibody, clone CPTC-CLIC1-1;store at +2℃ to +8℃，产品报价联系微信jinshanbio