货号：MABN462

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ASIC1 Antibody, clone N271/44 | MABN462 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of ASIC1. View All» Molecular Weight: ~60 kDa observed. Two isoforms at ~60 kDa and ~62 kDa are known to exist. View All» Epitope: C-terminus View All» Immunogen: Recombinant protein corresponding to the C-terminus of mouse ASIC1. View All» Clone: N271/44 View All» Isotype: IgG1κ View All» Background Information: Acid-sensing ion channels (ASICs) are broadly distributed in the nervous system where they contribute to certain sensory processes. In particular, they survey moderate decreases in extracellular pH as a means to regulate acid levels and acid-induced pain. ASICs thereby serve as a popular target for the treatment of acidosis. The acid-sensing ion channel 1 consists of a trimeric protein, where each subunit is composed of two transmembrane spanning helices, a highly organized ectodomain, and an intracellular N-terminus and C-terminus. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. View All» Application Notes: Western Blot: A representative lot detected ASIC1 in WT mice, but demonstrated a loss of signal in ASIC1 knockout mice.Immunohistochemistry Analysis: A representative lot detected ASIC1 in rat brain tissue (Prof. J. Trimmer, University of California, Davis). View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected ASIC1 in 10 µg of rat brain tissue lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6NXK8 View All» Entrez Gene Number: NP_033727 View All» Gene Symbol:
  • Asic1

  • Accn2

  • Asic

  • Bnac2
    View All» Alternate Names:
    • Acid-sensing ion channel 1

    • ASIC1

    • Acid-sensing ion channel

    • Amiloride-sensitive cation channel 2, neuronal

    • Brain sodium channel 2

    • BNaC2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Product Name: Anti-ASIC1, clone N271/44 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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