货号：MABN463

品牌：Merck Millipore

规格：

目录价：￥4497.00

市场价格：￥3822.45

会员价格：￥3597.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine D3 receptor Antibody, clone N331/19 | Cat. No. MABN463 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 44 kDa calculated View All» Immunogen: Recombinant protein corresponding to human Dopamine D3 receptor. View All» Clone: N331/19 View All» Isotype: IgG2aκ View All» Background Information: Dopamine is a widely distributed neurotransmitter produced by hydroxylation of L-tyrosine, followed by decarboxylation with DOPA decarboxylase. Dopamine exerts its actions by interacting with multiple classes of dopamine receptors that belong to the family of G protein-coupled receptors. Thus far five dopamine receptor subtypes have been reported that are classified into two main families based on their sequence and similarity in signal role. The D1-like dopamine receptors include the dopamine receptors D1 and D5. Binding of dopamine to these receptors leads to the activation of adenylyl cyclase, via a Gs protein, leading to increased cAMP production. The dopamine D2-like receptor group consists of D2, D3, and D4 receptors, which are coupled to Gi/o proteins and act by inhibiting adenylyl cyclase activity. D3 receptor subtype was first cloned and characterized by Sokoloff et al in 1990 (Nature 347, pp 146-151). D3 receptor coupling to various signal transduction mechanisms usually mimic those of D2 receptors, however, their cerebral distribution is very different. Highest expression of D3 receptors is found in ventral striatum in human brain. Dopamine D3 receptor represents a potential target for development of drugs to treat various neuropsychiatric and neurological disorders such as schizophrenia, Parkinson’s disease, drugs of abuse. View All» Species Reactivity:

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with Rat and Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 recpetor in rat cerebral cortex tissue. View All» Control: Rat thalamus tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat thalamus tissue.Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Dopamine D3 receptor in rat thalamus tissue. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35462 View All» Entrez Gene Number: NP_000787 View All» Gene Symbol: DRD3 View All» Alternate Names:
  • D(3) dopamine receptor

  • Dopamine D3 receptor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Immunocytochemistry
      View All» Product Name: Anti-Dopamine D3 receptor, clone N331/19 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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