货号：MABN494

品牌：Merck Millipore

规格：

目录价：￥4626.00

市场价格：￥3932.10

会员价格：￥3700.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fig4/Sac3 Antibody, clone N202/7 | Cat. No. MABN494 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of Fig4. View All» Molecular Weight: ~100 kDa observed View All» Epitope: C-terminus View All» Immunogen: Recombinant protein corresponding to the C-terminus of mouse Fig4/Sac3. View All» Clone: N202/7 View All» Isotype: IgG1κ View All» Background Information: Fig4/Sac3 phosphatase, a 97-kDa protein, specifically removes the 5-phosphate from the inositol ring of PI(3,5)P2, a membrane-bound phospholipid, which acts as a molecular signal for trafficking and fusion of intracellular vesicles. It is broadly expressed in all eukaryotic cells and plays a vital role in intracellular membrane trafficking and signaling. Mutations in Fig4/Sac3 have been linked to pale tremor mice that exhibit neuropathy with severe central and peripheral neuronal degeneration, including the loss of neurons in the dorsal root ganglion and the sciatic nerve. Fig4/Sac3 knockout mice have been shown to be smaller in size and exhibit abnormal tremor and gait and neuronal autophagy. Fig4/Sac3 deficiency is also reported to cause accumulation of cytoplasmic vacuoles in tissues, cultured fibroblasts, and neurons. Mutations in Fig4/Sac3 have been reported in patients with amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth Disease 4J that is characterized by severe motor dysfunction. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. Other Homologies: Human (91% sequence homology). View All» Application Notes: Western Blot Analysis: A representative lot from an independent laboratory detected Fif4/Sac3 in adult rat brain membrane and in WT mouse brain lysate, and demonstrated a loss of signal in Fif4/Sac3 knockout mouse brain lysate.Western Blot Analysis: A representative lot from an independent laboratory detected Fig4/Sac3 in mouse brain and in P4 spinal chord protein extracts (Yan, Q., et al. (2012). J Neurol Sci. 312(1-2):102-107.). View All» Control: Neuro-2a cell lysate View All» Quality Assurance: Evaluated by Western Blot in Neuro-2a cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Fig4/Sac3 in 10 µg of Neuro-2a cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q91WF7 View All» Entrez Gene Number: NP_598760 View All» Gene Symbol:
  • Fig4

  • Sac3
    View All» Alternate Names:
    • Polyphosphoinositide phosphatase

    • Phosphatidylinositol 3,5-bisphosphate 5-phosphatase

    • SAC domain-containing protein 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Fig4/Sac3, clone N202/7 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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