货号：MABN50A4

品牌：Merck Millipore

规格：100UL

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate | MABN50A4 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Molecular Weight: The unconjugated parent antibody (Cat. No. MABN50) has an observed molecular weight at ~37 kDa. View All» Immunogen: Recombinant protein corresponding to human Olig2. View All» Clone: 211F1.1 View All» Isotype: IgG2a View All» Background Information: Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse and rat. Predicted to react with human based on 100% sequence homology View All» Control: Rat oligodendrocyte precursor cells View All» Quality Assurance: Evaluated by Immunocytochemistry in rat oligodendrocyte precursor cells.Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Olig2 in rat oligodendrocyte precursor cells. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2a conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: Q13516 View All» Entrez Gene Number: NP_005797 View All» Gene Symbol:
  • OLIG2

  • BHLHB1

  • BHLHE19

  • PRKCBP2

  • RACK17
    View All» Alternate Names:
    • Oligodendrocyte transcription factor 2

    • Oligo2

    • Class B basic helix-loop-helix protein 1

    • bHLHb1

    • Class E basic helix-loop-helix protein 19

    • bHLHe19

    • Protein kinase C-binding protein 2

    • Protein kinase C-binding protein RACK17
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» Entrez Gene Summary: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).SIZE: 323 amino acids; 32385 Da SUBUNIT: Interacts with NKX2-2 (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity).DISEASE:SwissProt: Q13516 # A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain. View All» Product Name: Anti-Olig2, clone 211F1.1, Alexa Fluor®488 Conjugate View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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      © Merck Millipore代理MABN50A4 Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate | MABN50A4;抗-Olig2抗体，克隆211F1.1，Alexa F，产品报价联系微信jinshanbio