货号：MABN76

品牌：Merck Millipore

规格：

目录价：￥3990.00

市场价格：￥3391.50

会员价格：￥3192.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel Kv1.3 Antibody, clone L23/27 | MABN76 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Kv1.3 at the C-terminus. View All» Molecular Weight: ~58 kDa observed. The molecular weight band at ~ 150 kDa could be the heterotetramer of Kv1.3. The ~ 23kDa band could be a truncate fragment of kv1.3 truncate fragment. (Tu, L., et al. (1996) J. Biol. Chem. 271(31):18904−18911.) View All» Epitope: C-terminus View All» Immunogen: Linear peptide corresponding to rat Kv1.3 at the C-terminus. View All» Clone: L23/27 View All» Isotype: IgG2a View All» Background Information: Potassium channel Kv1.3 is a voltage gated channel most commonly found in the plasma membrane, and recently also found in the inner mitochondrial membrane. It is thought that Kv1.3 is instrumental in the apoptosis signaling pathway. During the onset of apoptosis, Bax binds to Kv1.3 and hinder its function, this action causes hyperpolarization. This increases the production of reactive oxygen species and cytochrome c. Kv1.3 may also be a member of the pathway in cells outside of just lymphocytes. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Application Notes: Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Doczi, M., et al. (2008). Am J Physiol Regul Integr Comp Physiol 295:R733-R740.) View All» Control: Rat brain membrane prep tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane prep tissue lysate.Western Blot Analysis: 5 µg/mL of this antibody detected Kv1.3 on 10 µg of rat brain membrane prep tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15384 View All» Gene Symbol:

• KCNA3

• HLK3

• HGK5

• KV1.3

• HuKIII

• HPCN3

• Kv1.3

• MK3

• HUKIII

• PCN3
  View All» Alternate Names:
  • potassium voltage-gated channel, shaker-related subfamily, member 3

  • potassium channel 3

  • potassium voltage-gated channel subfamily A member 3

  • voltage-gated potassium channel protein Kv1.3

  • Voltage-gated potassium channel subunit Kv1.3

  • Voltage-gated K(+) channel HuKIII

  • type n potassium channel
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.SUBUNIT STRUCTURE: Heterotetramer of potassium channel proteins (By similarity). Binds PDZ domains of DLG1, DLG2 and DLG4.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SEQUENCE SIMILARITIES: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily. [View classification] View All» Product Name: Anti-Potassium Channel Kv1.3, clone L23/27 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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