货号：MABN88

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12 | MABN88 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes KCC2 View All» Molecular Weight: 126 kDa Calculated View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to rat KCC2. View All» Clone: N1/12 View All» Isotype: IgG2aκ View All» Background Information: KCC2 is a member of the cation-chloride cotransporter gene family. It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain. KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord. Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior. View All» Species Reactivity:

• Rat

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with rat. Shown by an independent laboratory to react in human and mouse tissue. (UC Davis/NIH NeuroMab Facility Department of Neurobiology, Physiology and Behavior) View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected KCC2 in rat hypothalamus tissue. View All» Control: Rat cortex area A-3 tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in rat cortex area A-3 tissue.Immunohistochemistry Analysis: 1:300 dilution of this antibody detected KCC2 in rat cortex area A-3 tissue. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q63633 View All» Entrez Gene Number: NP_599190 View All» Gene Symbol:
  • SLC12A5

  • KIAA1176

  • hKCC2

  • KCC2
    View All» Alternate Names:
    • Electroneutral potassium-chloride cotransporter 2

    • Erythroid K-Cl cotransporter 2

    • Neuronal K-Cl cotransporter

    • electroneural potassium-chloride cotransporter 2

    • solute carrier family 12

    • potassium-chloride transporter), member 5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: Neuronal specific potassium-chloride cotransporter isoform; may play a role in response to neuronal injury [RGD]. View All» UniProt Summary: FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl- homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development. SUBUNIT STRUCTURE: Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICTY: Highly expressed in brain. Not detected in other tissues. Highly expressed in pyramidal neurons and in neurons throughout the cortex, hippocampus, the granular layer of the cerebellum and in groups of neurons throughout the brainstem. Barely detectable in dorsal-root ganglions.DEVELOPMENTAL STAGE: Detected in thalamus, but not in hippocampus and neocortex at E20. At birth barely detectable in hippocampus. Expression increases steeply from day 5 to day 9 and then stabilizes at adult levels.SEQUENCE SIMILARITIES: Belongs to the SLC12A transporter family. View All» Product Name: Anti-K+/Cl- Cotransporter (KCC2), clone N1/12 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MABN88 Anti-K+/Cl- Cotransporter (KCC2) Antibody, clone N1/12;抗-K+/Cl-协同转运蛋白（KCC2）抗体，克隆N1/12store at +2℃ to，产品报价联系微信jinshanbio