货号：MABS12

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GRK6 Antibody, clone 4B11.2 | MABS12 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~75 kDa observed. 66 kDa calculated. View All» Epitope: 0 View All» Immunogen: Histidine-tagged recombinant protein corresponding to human GRK6. View All» Clone: 4B11.2 View All» Isotype: IgG2aκ View All» Background Information: G protein-coupled receptor kinase 6 (GRK6) is a widely expressed member of the AGC Ser/Thr protein kinase family and is comprised of an AGC-kinase C-terminal domain, a protein kinase domain, and a RGS domain. GRK6, like other GRKs, possesses unique activity against activated G protein-coupled receptors, which serves to regulate activation-dependent desensitization of the GPCR active forms. Studies have shown a critical role for GRK6 in the regulation of lymphocyte CXCR4 activity. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GRK6 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P43250 View All» Entrez Gene Number: NP_001004105 View All» Gene Symbol:
  • GRK6

  • GPRK6
    View All» Alternate Names:
    • G protein-coupled receptor kinase 6

    • G protein-coupled receptor kinase GRK6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors.CATALYTIC ACTIVITY: ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.SUBCELLULAR LOCATION: Membrane; Lipid-anchor. TISSUE SPECIFICTY: Widely expressed. PTM: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 RGS domain. View All» Product Name: Anti-GRK6, clone 4B11.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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