货号：MABS16

品牌：Merck Millipore

规格：EA

目录价：￥3228.00

市场价格：￥2743.80

会员价格：￥2582.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AKAP-9 Antibody | MABS16 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 454 kDa calculated. View All» Epitope: 0 View All» Immunogen: Histidine tagged recombinant protein corresponding to rabbit AKAP9. View All» Clone: 14G2 View All» Isotype: IgG1κ View All» Background Information: A-kinase anchor protein 9 (AKAP-9) is a multi-functional PKA anchoring protein belonging to the AKAP family of proteins, known for their ability to bind the PKA regulatory subunit. AKAP-9 is comprised of a PPI-binding site, an RII-binding site, two LZ motifs, and seven LIZ motifs. Specifically, AKAP-9 binds to PKA type II regulatory subunits. It serves as a scaffolding protein by collecting various phosphatases and kinases to the centrosome and the Golgi apparatus. AKAP-9 is potentially a required component for upkeep of the integrity of Golgi apparatus. Expression is high in gastric parietal cells. A splice variant of AKAP-9, Yotiao, is the cause of long-QT syndrome and has been associated with adenylyl cyclases of the brain and heart. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Expected to react with rabbit due to sequence similarity (100% homologous). View All» Control: HeLa cells View All» Quality Assurance: Evaluated by Immunocytochemistry in HeLa cells.Immunocytochemistry Analysis: 1:500 dilution of this antibody detected AKAP9 in HeLa cells. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl without 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q28628 View All» Entrez Gene Number: NP_001075820 View All» Gene Symbol:

• AKAP450

• AKAP350: AKAP 450

• CG-NAP

• hgAKAP 350

• PRKA9

• AKAP-9

• YOTIAO

• AKAP 350

• AKAP9
  View All» Alternate Names:
  • A kinase (PRKA) anchor protein (yotiao) 9

  • A-kinase anchor protein 350 kDa

  • AKAP 120-like protein

  • A-kinase anchor protein 450 kDa

  • AKAP120-like protein

  • A-kinase anchoring protein 450

  • HYPERION

  • protein kinase A anchoring protein 9

  • Centrosome- and Golgi-localized PKN-associated protein

  • A-kinase anchor protein 9

  • Protein yotiao

  • kinase N-associated protein

  • Protein hyperion

  • centrosome- and golgi-localized protein

  • Protein kinase A-anchoring protein 9

  • A-kinase anchor protein, 350kDa

  • AKAP9-BRAF fusion protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» UniProt Summary: FUNCTION: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus (By similarity).SUBUNIT STRUCTURE: Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm By similarity. Cytoplasm › cytoskeleton › centrosome (By similarity). Golgi apparatus By similarity. Note: Cytoplasmic in parietal cells (By similarity).TISSUE SPECIFICTY: Highly expressed in gastric parietal cells. DOMAIN: RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.SEQUENCE CAUTION: The sequence AAC35413.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-AKAP-9 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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