货号：MABS169

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ERK3 Antibody, clone EP1720Y, Rabbit | MABS169 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes ERK3 at the N-terminus. View All» Molecular Weight: ~105 kDa observed View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to human ERK3 at the N-terminus. View All» Clone: EP1720Y View All» Isotype: IgG View All» Background Information: ERK3 (Extracellular signal-regulated kinase 3, MAPK6, p97 MAPK) belongs to the Ser/Thr protein kinase family and is a member of the mitogen-activated protein (MAP) kinase superfamily. Unlike the other members of the MAPK family, ERK3 is a mitogen-activated protein kinase homologue that has SEG motif instead of conserved TXY motif in the activation loop (1). Also, unlike ERK1 and ERK2, it is ubiquitously expressed and localized in the nucleus of proliferating cells (2). Highly unstable, ERK3 is constitutively degraded during ubiquitin-proteasome pathway of proliferating cells (3). ERK3 has been linked to phosphorylation MAP2 and as a possible regulator during cell differentiation (4). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse and Rat. View All» Application Notes: Flow Cytometry Analysis: A 1:45 dilution from a representative lot was used in FC.Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected ERK3 in human breast carcinoma tissue. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected ERK3 in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q16659 View All» Entrez Gene Number: Q16659 View All» Gene Symbol:
  • ERK3

  • HsT17250

  • p97MAPK

  • ERK-3

  • PRKM6

  • MAPK 6

  • p97-MAPK

  • EC 2.7.11.24

  • DKFZp686F03189
    View All» Alternate Names:
    • mitogen-activated protein kinase 6

    • Extracellular signal-regulated kinase 3

    • MAP kinase 6

    • MAP kinase isoform p97

    • extracellular signal-regulated kinase, p97

    • protein kinase, mitogen-activated 5

    • protein kinase, mitogen-activated 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Flow Cytometry
        View All» UniProt Summary: FUNCTION: Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle By similarity.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium By similarity.ENZYME REGULATION: Activated by threonine and tyrosine phosphorylation By similarity.TISSUE SPECIFICITY Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme By similarity. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-ERK3, clone EP1720Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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