货号：MABS172

品牌：Merck Millipore

规格：

目录价：￥3358.00

市场价格：￥2854.30

会员价格：￥2686.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FABP4 Antibody, clone EPR3579, Rabbit | MABS172 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Molecular Weight: ~15 kDa observed View All» Immunogen: Synthetic peptide corresponding to human FABP4. View All» Clone: EPR3579 View All» Isotype: IgG View All» Background Information: Fatty acid binding proteins (FABPs) are proteins that reversibly bind fatty acids and other lipids. So far, nine tissue-specific cytoplasmic FABPs have been identified. Functions attributable to these lipid binding proteins remain unclear, but data are presented that indicate physiological roles in 1) fatty acid transport, esterification, and oxidation, 2) steroidogenesis, and 3) retinoid uptake, retinaldehyde reduction, and retinol esterification (1). Adipose tissue FABP (FABP4) binds both long chain fatty acids and retinoic acid (2). It delivers retinoic acid to nulear trans-acting proteins, thereby modulates genes coding for key proteinsinvolved in lipid metabolism or differentiation. FABP4 is closely associated with metabolic syndrome, type 2 diabetes, and atheroscelerosis (3,4). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Control: Human adipose and fetal heart tissue lysates View All» Quality Assurance: Evaluated by Western Blot in human adipose and fetal heart tissue lysates.Western Blot Analysis: A 1:1,000-1:5,000 dilution of this antibody detected FABP4 in human adipose and fetal heart tissue lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P15090 View All» Entrez Gene Number: P15090 View All» Gene Symbol:
  • A-FABP

  • aP2

  • AFABP

  • ALBP
    View All» Alternate Names:
    • fatty acid binding protein 4, adipocyte

    • Adipocyte lipid-binding protein

    • Adipocyte-type fatty acid-binding protein

    • Fatty acid-binding protein 4

    • fatty acid-binding protein, adipocyte
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus By similarity.SUBUNIT STRUCTURE: Homodimer. Interacts with PPARG By similarity. Monomer. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note: Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export By similarity.DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.SEQUENCE SIMILARITIES: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. View All» Product Name: Anti-FABP4, clone EPR3579, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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      © Merck Millipore代理MABS172 Anti-FABP4. clone EPR379, Rabbit Monoclonal，产品报价联系微信jinshanbio