货号：MABS179

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Thioredoxin Reductase 2 Antibody, clone 1C4 | MABS179 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~57 kDa observed View All» Immunogen: Linear peptide corresponding to mouse Thioredoxin Reductase 2. View All» Clone: 1C4 View All» Isotype: IgG2aκ View All» Background Information: Respiring mitochondria continuously produce H2O2. When production exceeds scavenging, H2O2 levels rise to a state, which can endanger cellular functions. The mitochondrial peroxidase peroxiredoxin-3 reduces H2O2 into water by utilizing reducing equivalents from NADPH supplied by Thioredoxin 2 (Trx2) and, ultimately, Thioredoxin Reductase 2 (TrxR2). Inhibition of TrxR2 has been shown to disturb mitochondrial redox balance, increase H2O2 emission, and ultimately contribute to cardiac dysfunction. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected Thioredoxin Reductase 2 in mouse liver tissue lysate.Western Blot Analysis: 0.5 µg/mL from a representative lot detected Thioredoxin Reductase 2 in mouse kidney tissue lysate. View All» Control: NIH3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH3T3 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Thioredoxin Reductase 2 in 10 µg of NIH3T3 cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9JLT4 View All» Entrez Gene Number: NP_038739 View All» Gene Symbol:

• Txnrd2

• Trxr2
  View All» Alternate Names:
  • Thioredoxin reductase 2, mitochondrial

  • Thioredoxin reductase TR3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene product belongs to the family of pyridine nucleotide-disulfide oxidoreductases. It is a mitochondrial enzyme that catalyzes the reduction of thioredoxin, and is implicated in the defense against oxidative stress. This protein contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. View All» UniProt Summary: FUNCTION: Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.CATALYTIC ACTIVITY: Thioredoxin + NADP+ = thioredoxin disulfide + NADPH.COFACTOR: FAD.SUBUNIT STRUCTURE: Homodimer.SUBCELLULAR LOCATION: Mitochondrion.TISSUE SPECIFICITY: Expressed in liver, heart, testis and kidney. View All» Product Name: Anti-Thioredoxin Reductase 2, clone 1C4 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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