货号：MABS273

品牌：Merck Millipore

规格：

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Abl interactor 1 Antibody, clone W8-3 | MABS273 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~55 kDa observed View All» Immunogen: Linear peptide corresponding to human Abl interactor 1. View All» Clone: W8-3 View All» Isotype: IgG1κ View All» Background Information: Abl interactor 1 (Abelson interactor 1, Abi-1, e3B1) is a member of the family of Abl-interactors and is highly expressed in the brain. Abl interactor 1 is involved in the signaling of ABL1 and ABL2 nonreceptor tyrosine kinases, and the EGF-receptor. The Abl interactor 1 protein contains SH3 domains, and may function as an adaptor protein: It forms a trimeric complex with EPS8 and SOS1 in the transduction of signals from Ras to Rac. Previous studies have suggested that Abl interactor 1 via the Ras and Rac pathways may regulate cell proliferation, cell adhesion, and actin remodeling. Abl interactor 1 is also investigated for its role in tumor suppression. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Abl interactor 1 in EGF treated Cos-7 cell lysate (Innocenti, M, et al. (2004). Nat Cell Biol. 6(4):319-327.)Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated Abl interactor 1 in GFP-Abl interactor 1 transfected HeLa cells (Innocenti, M, et al. (2004). Nat Cell Biol. 6(4):319-327.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Abl interactor 1 in 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IZP0 View All» Entrez Gene Number: NP_001012768 View All» Gene Symbol:

• ABI1

• SSH3BP1
  View All» Alternate Names:
  • Abl interactor 1

  • Abelson interactor 1

  • Abi-1

  • AblBP4

  • Eps8 SH3 domain-binding protein

  • Eps8-binding protein

  • Eps8-binding protein

  • Nap1-binding protein

  • Nap1-binding protein

  • Nap1BP

  • Spectrin SH3 domain-binding protein 1

  • e3B1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry

    • Immunoprecipitation
      View All» Product Name: Anti-Abl interactor 1, clone W8-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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