货号：MABS31

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2 | MABS31 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~10 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human Calcyclin.Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program. View All» Clone: CPTC-Calcyclin-2 View All» Isotype: IgG2aκ View All» Background Information: Calcyclin, also known as S100A6, is a calcium binding protein that is highly expressed in fibroblasts and epithelial cells. Inhibition of calcyclin by p53 is part of the mechanism to control cell proliferation. Calcyclin is associated with cancer and metastasis and plays a role in cell cycle regulation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.) View All» Control: Human lung tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human lung tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Calcyclin on 10 µg of human lung tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P06703 View All» Entrez Gene Number: NP_055439 View All» Gene Symbol:

• MLN 4

• PRA

• CACY

• CABP

• 2A9

• 5B10
  View All» Alternate Names:
  • S100 calcium binding protein A6

  • S100 calcium binding protein A6 (calcyclin)

  • protein S100-A6

  • calcyclin

  • S100 calcium-binding protein A6 (calcyclin)

  • Growth factor-inducible protein 2A9

  • Calcyclin

  • Prolactin receptor-associated protein

  • S100 calcium-binding protein A6
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May function as calcium sensor and contribute to cellular calcium signaling Potential. May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.SUBUNIT STRUCTURE: Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP (By similarity). Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. SUBCELLULAR LOCATION: Nucleus envelope. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side INDUCTION: Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.PTM: The N-terminus is blocked.MISCELLANEOUS: This protein co-purified with the prolactin receptor.SEQUENCE SIMILARITIES: Belongs to the S-100 family.Contains 2 EF-hand domains. View All» Product Name: Anti-Calcyclin, clone CPTC-Calcyclin-2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-133193.htm
      © Merck Millipore代理MABS31 Anti-Calcyclin Antibody, clone CPTC-Calcyclin-2;store at +2℃ to +8℃，产品报价联系微信jinshanbio