货号：MABS32

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GCLM Antibody, clone CPTC-GCLM-3 | MABS32 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 31 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human GCLM.Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program. View All» Clone: CPTC-GCLM-3 View All» Isotype: IgG2aκ View All» Background Information: Glutamate-cysteine ligase modifier subunit (GCLM) is one of two parts of glutamate-cysteine ligase (GCL). GCL is responsible for catalyzing the rate-limiting step in the synthesis of cellular antioxidant glutathione (GSH). With the introduction of oxidative stress, GCLM was modified from its monomeric form to a holoenzyme. There is evidence that a functional mutation in GCLM could leave a patient with a predisposition to schizophrenia. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GCLM on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P48507 View All» Entrez Gene Number: NP_002052 View All» Gene Symbol:

• GLCLR

• GCLM3
  View All» Alternate Names:
  • glutamate-cysteine ligase, modifier subunit

  • GCS light chain

  • glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory (30.8kD)

  • Gamma-ECS regulatory subunit

  • GSC light chain

  • Glutamate--cysteine ligase modifier subunit

  • glutamate--cysteine ligase regulatory subunit

  • Gamma-glutamylcysteine synthetase regulatory subunit

  • glutamate-cysteine ligase regulatory protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. [provided by RefSeq]. View All» UniProt Summary: PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.SUBUNIT STRUCTURE: Heterodimer of a catalytic heavy chain and a regulatory light chain.TISSUE SPECIFICTY: In all tissues examined. Highest levels in skeletal muscle.SEQUENCE SIMILARITIES: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily. View All» Product Name: Anti-GCLM, clone CPTC-GCLM-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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