货号：MABS50

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cdk5 Antibody, clone 1H3 | MABS50 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CDK5. View All» Molecular Weight: 33 kDa observed View All» Immunogen: Human CDK5 cross linked to homogenized surgical suture material View All» Clone: 1H3 View All» Isotype: IgG1κ View All» Background Information: Cyclin-dependent kinase 5 (CDK5), belongs to the cyclin-dependent kinase family. It is most active in the central nervous system and plays an important role in the regulation of cytoskeletal function. CDK5 expression has been observed in testis, kidney, and ovary with higher levels seen in postmitotic neurons in developing and adult nervous systems. Mutations in CDK5 have been associated with Alzheimer's disease, Parkinson's disease, and ALS, suggesting that CDK5 may play a key role in several neurodegenerative disorders. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse and rat based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: This antibody has been shown to detect CDK5 in mouse brain histological sections. (Legace, D.C., et al. (2008). Proc Natl Acad Sci USA. 105:18567-18571.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected CDK5 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q00535 View All» Entrez Gene Number: NP_004926 View All» Gene Symbol:
  • CDK5

  • PSSALRE
    View All» Alternate Names:
    • cyclin-dependent kinase 5

    • Tau protein kinase II catalytic subunit

    • Serine/threonine-protein kinase PSSALRE

    • protein kinase CDK5 splicing

    • TPKII catalytic subunit
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.SIZE: 292 amino acids; 33304 Da SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit (p35). Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity). Interacts with AATK.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, lamellipodium (By similarity). Cell projection, growth cone (By similarity). Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. & Contains 1 protein kinase domain. ... hide » see more » View All» Product Name: Anti-Cdk5, clone 1H3 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Soma View All» Format: Purified View All» Host: Mouse View All»
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