货号：MABS56

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NDR1/2 protein kinase Antibody, clone BH6-31G14 | MABS56 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NDR1/2 kinase protein. View All» Molecular Weight: ~ 54 kDa observed View All» Immunogen: Mal-tagged (Maltose Binding Protein) recombinant protein corresponding to human NDR1/2 kinase protein. View All» Clone: BH6-31G14 View All» Isotype: IgG1κ View All» Background Information: Nuclear DFB-2-related (NDR) kinases are a highly conserved, subclass of the AGC protein kinase group that are known to be regulated by Mps One Binding (MOB) binding partner through binding and subsequent activation. They can also be activated by phosphorylation to the hydrophobic motif at the C-terminal and the kinase domain activation loop. NDR kinases play an integral role as regulators in several cellular processes such as; cytokinesis, mitotic exit, centrosome duplication, cell growth, morphogenesis, and development. NDR1 and NDR2 are two serine-threonine kinases belonging to the NDR kinase family that share significant homology with each other. NDR1 autophosphorylation is induced by Ca2+ in addition to phosphorylation by an unknown upstream kinase. Both NDR1 and NDR2 are nearly ubiquitous in expression, with the exception of NDR1 not being observed in the brain. In contrast, NDR2 has highest expression in the thymus. Studies have suggested the NDR1 may be involved in tumor progression and NDR2 in either tumor initiation or progression. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NDR1/2 kinase protein on 10 µg of Jurkat cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15208 View All» Entrez Gene Number: NP_009202 View All» Gene Symbol:

• NDR1

• NDR

• STK38
  View All» Alternate Names:
  • serine/threonine kinase 38

  • nuclear Dbf2-related 1

  • NDR1 protein kinase

  • Nuclear Dbf2-related kinase 1

  • Ndr Ser/Thr kinase-like protein

  • serine threonine protein kinase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA
      View All» UniProt Summary: FUNCTION: Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its nonphosphorylated form and inhibits autophosphorylation of MAP3K2.CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium. ENZYME REGULATION: Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-281. Thr-444 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-444 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38. SUBUNIT STRUCTURE: Homodimeric S100B binds two molecules of STK38. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with MOB1 and MOB2. Interacts with MAP3K1 and MAP3K2 (via the kinase catalytic domain). SUBCELLULAR LOCATION: Nucleus. Cytoplasm TISSUE SPECIFICITY: Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain. View All» Product Name: Anti-NDR1/2 protein kinase, clone BH6-31G14 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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