货号：MABS64

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2 | MABS64 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes p38 when phosphorylated at Thr180 and Tyr182. View All» Molecular Weight: 41 kDa observed View All» Epitope: Phosphorylated Thr180 and Tyr182 View All» Immunogen: Linear peptide corresponding to human p38 phosphorylated at Thr180 and Tyr182. View All» Modifications: Phosphorylation View All» Clone: 6E5.2 View All» Background Information: The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected p38 in Anisomycin treated NIH/3T3 cells. View All» Control: Anisomycin treated and untreated HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in Anisomycin treated and untreated HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected p38 on 10 µg of Anisomycin treated and untreated HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgGκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q16539 View All» Entrez Gene Number: NP_001306.1 View All» Gene Symbol:
  • SAPK2a

  • MAPK14

  • CSBP1

  • CSBP2

  • CSPB1

  • PRKM14

  • PRKM15

  • p38ALPHA

  • RK

  • Mxi2

  • EXIP
    View All» Alternate Names:
    • mitogen-activated protein kinase 14

    • cytokine suppressive anti-inflammatory drug binding protein

    • stress-activated protein kinase 2A

    • Cytokine suppressive anti-inflammatory drug-binding protein

    • CSAID-binding protein

    • MAP kinase MXI2

    • MAX-interacting protein 2

    • CSAID-binding protein

    • Mitogen-activated protein kinase p38 alpha

    • p38 MAP kinase

    • p38 mitogen activated protein kinase

    • MAP kinase p38 alpha

    • Csaids binding protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Responds to activation by environmental stress, pro- inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.COFACTOR: Magnesium.SIZE: 360 amino acids; 41293 Da SUBUNIT: Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (by similarity). Interacts with NP60.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).TISSUE SPECIFICITY: Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.DOMAIN:SwissProt: Q16539 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme. & Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Product Name: Anti-phospho-p38 (Thr180/Tyr182), clone 6E5.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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