货号：MABS66

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rho (-A, -B, -C) Antibody, clone 10F11.2 | MABS66 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Rho (-A, -B, -C). View All» Molecular Weight: ~22 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to human Rho (-A, -B, -C). View All» Clone: 10F11.2 View All» Isotype: IgG1κ View All» Background Information: Rho proteins belong to the Ras super family of low molecular weight GTPases, which includes RAS, RHO, RAB, RAN, RAD and ARF. These small GTP binding proteins function as molecular switches that regulate a multitude of biological processes including cell proliferation, apoptosis, differentiation, cytoskeletal reorganization, and membrane trafficking. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution of a previous lot detected Rho (-A, -B, -C) in HeLa, A431 and HL60 cells. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Rho (-A, -B, -C) on 10 µg of mouse brain tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P62745 View All» Entrez Gene Number: NP_004031 View All» Gene Symbol:

• RhoB

• MST081

• MSTP081

• RHOH6

• ARH6

• ARHB

• H6
  View All» Alternate Names:
  • ras homolog gene family, member B

  • oncogene RHO H6

  • Aplysia RAS-related homolog 6
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. SUBUNIT STRUCTURE: Binds ROCK1 and ROCK2. Also binds PKN1/PRK1. Interacts with ARGGEF3, RTKN and AKAP13. SUBCELLULAR LOCATION: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Note: Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. PTM: Prenylation specifies the subcellular location of RHOB. The farnesylated form is localized to the plasma membrane while the geranylgeranylated form is localized to the endosome.MISCELLANEOUS: RHOB is one of the targets of farnesyltransferase inhibitors which are currently under investigation as cancer therapeutics. These elevate the levels of geranylgeranylated RHOB and cause mislocalization, leading to apoptosis and antineoplastic effects.SEQUENCE SIMILARITIES: Belongs to the small GTPase superfamily. Rho family. View All» Product Name: Anti-Rho (-A, -B, -C), clone 10F11.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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