货号：MABS77

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GSK-3 alpha/beta Antibody, clone 12B11.1 | MABS77 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~46/51 kDa observed View All» Immunogen: Ovalbumin-conjugated linear peptide corresponding to human GSK-3 alpha/beta. View All» Clone: 12B11.1 View All» Isotype: IgMκ View All» Background Information: Glycogen synthase-3 alpha (GSK-3 alpha) is a ubiquitous constitutively-active multifunctional kinase. GSK-3 alpha phosphorylates serine and threonine residues on its target substrates, most of which are “primed” or prephosphorylated. It is most widely researched for its interaction with glycogen synthase which is deactivated after phosphorylation by GSK-3 alpha; this activity blocks the synthesis of glycogen and plays an important role in the regulation of glycogen. GSK-3 alpha is also involved in the Wnt/β-catenin, Notch, and Hedgehog signaling pathways and affects a wide range of cellular processes including cell-cycle regulation, transcription, and apoptosis. GSK-3 alpha also phosphorylates tau proteins and may contribute to the generation of APP-derived amyloid plaques which are involved in the pathogenesis of Alzheimer’s disease. GSK-3 alpha is also investigated for its role in type 2 diabetes, and cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected GSK-3 alpha/beta in HeLa and A431 cells. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected GSK-3 alpha/beta on 10 µg of Jurkat cell lysate. View All» Purification Method: Purified by ion exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P49840 View All» Entrez Gene Number: NP_063937 View All» Gene Symbol:

• GSK3A

• GSK-3 alpha/beta
  View All» Alternate Names:
  • Glycogen synthase kinase-3 alpha

  • GSK-3 alpha

  • Serine/threonine-protein kinase GSK3A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]. View All» UniProt Summary: FUNCTION: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. CATALYTIC ACTIVITY: ATP + [tau protein] = ADP + [tau protein] phosphate.ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Activated by phosphorylation at Tyr-279. In response to insulin, inhibited by phosphorylation at Ser-21 by PKB/AKT1; phosphorylation at this site causes a conformational change, preventing access of substrates to the active site. Inhibited by lithium.SUBUNIT STRUCTURE: Monomer. Interacts with ARRB2 (By similarity). Interacts with AXIN1 and CTNNB1/beta-catenin. PTM: Phosphorylated by AKT1 at Ser-21: upon insulin-mediated signaling, the activated PKB/AKT1 protein kinase phosphorylates and desactivates GSK3A, resulting in the dephosphorylation and activation of GYS1. Activated by phosphorylation at Tyr-279.MISCELLANEOUS: Higher expression and activity of GSK3A are found in the skeletal muscle (vastus lateralis) of patients with type 2 diabetes (Ref.5). Several potent GSK3 (GSK3A and GSK3B) inhibitors have been identified and characterized in preclinical models for treatments of type 2 diabetes (Ref.17).SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-GSK-3 alpha/beta, clone 12B11.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-133212.htm
      © Merck Millipore代理MABS77 Anti-GSK-3 alpha/beta, clone 12B11.1，产品报价联系微信jinshanbio