货号：MABT104

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myotubularin Antibody, clone 9G3.2 | MABT104 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~70 kDa observed. Uncharacterized bands may be observed ~30 kDa, ~55 kDa, and ~58 kDa in some tissue lysates. View All» Immunogen: GST-tagged recombinant protein corresponding to human Myotubularin. View All» Clone: 9G3.2 View All» Isotype: IgMκ View All» Background Information: Myotubularin is a cytoplasmic phosphatase which belongs to the protein-tyrosine phosphatase family. It contains a GRAM domain and a myotubularin phosphatase domain. Myotubularin targets phosphoinositide substrates, including phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). It may also dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Myotubularin indirectly regulates many cellular processes that are facilitated by phosphoinositides, and plays an important role in the formation and morphology of membrane-bound intracellular structures such as vacuoles and mitochondria. It also regulates the transport of EGFR from late endosomes to lysosomes, resulting in the degradation of EGFR. Defects in myotubularin result in X-linked myotubular myopathy, a congenital muscle-wasting condition that affects the limb girdle, trunk, and neck muscles. It has also been implicated in other neuromuscular diseases, such as Charcot-Marie-Tooth disease type 4B. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Western Blot Analysis: 0.2 µg/mL of this antibody detected Myotubularin in mouse liver tissue lysate. View All» Control: Rat liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat liver tissue lysate.Western Blot Analysis: 0.2 µg/mL of this antibody detected Myotubularin in rat liver tissue lysate. View All» Purification Method: Purified by ion-exchange chromatography. View All» Presentation: Purified mouse monoclonal IgMκ supernatant in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13496 View All» Entrez Gene Number: NP_000243 View All» Gene Symbol:
  • MTM1

  • CG2
    View All» Alternate Names: Myotubularin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Myotubularin, clone 9G3.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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