货号：MABT147

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MMP-12 (C-terminus) Antibody, clone EP1261Y, Rabbit | MABT147 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MMP-12 at the C-terminus. View All» Molecular Weight: ~45 kDa observed. In Western Blot, depending on the lysate used, this antibody may identify bands at ~54 kDa (zymogen), ~45 kDa (activated form), and ~22 kDa (common form). View All» Immunogen: Synthetic peptide corresponding to human MMP-12 at the C-terminus. View All» Clone: EP1261Y View All» Isotype: IgG View All» Background Information: Human macrophage elastase (MMP-12) is a member of the family of matrix metalloproteinases (MMPs) that plays, like other members of the family, an important role in inflammatory processes contributing to tissue remodeling and destruction. In particular, a prominent role of MMP-12 in the destruction of elastin in the lung alveolar wall and the pathogenesis of emphysema has been suggested (1). MMP-12 expressed mainly in alveolar macrophages has been identified in the mouse lung as the main destructive agent associated with cigarette smoking, which gives rise to emphysema, both directly via elastin degradation and indirectly by disturbing the proteinase/antiproteinase balance via inactivation of the alpha1-proteinase inhibitor (alpha1-PI), the antagonist of the leukocyte elastase (2). Because elastin represents a critical component of aortic wall structure and a matrix substrate for metalloelastases, MMP-12 may have a direct and singular role in the pathogenesis of aortic aneurysms (3). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunoprecipitation Analysis: 1:30 dilution from a representative lot was used in IP.Flow Cytometry Analysis: 1:10 dilution from a representative lot was used in FC.Immunohistochemistry Analysis: 1:100-1:250 dilution from a representative lot detected MMP-12 in human breast carcinoma tissue.Immunocytochemistry Analysis: 1:100-250 dilution from a representative lot was used to detect MMP-12 in HeLa cells. View All» Control: Recombinant MMP-12 protein View All» Quality Assurance: Evaluated by Western Blot in recombinant MMP-12 protein.Western Blot Analysis: 1:2,000 dilution of this antibody detected MMP-12 in recombinant MMP-12 protein. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below-20°C may cause glycerol containing Solutions to become frozen during storage. View All» UniProt Number: P39900 View All» Gene Symbol:
  • HME

  • MME

  • MMP-12

  • ME

  • MGC138506

  • hME

  • EC 3.4.24.65
    View All» Alternate Names:
    • matrix metallopeptidase 12 (macrophage elastase)

    • matrix metalloproteinase 12 (macrophage elastase)

    • Macrophage elastase

    • Matrix metalloproteinase-12

    • macrophage metalloelastase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)

      • Flow Cytometry

      • Immunoprecipitation
        View All» Product Name: Anti-MMP-12 (C-terminus), clone EP1261Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Diluted Culture Supernatant View All» Host: Rabbit View All»
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