货号：MABT18

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin alpha5 (CD49e) Antibody, clone MFR5 (5H10-27) | MABT18 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 115 kDa calculated View All» Immunogen: Mouse mast cell line MC/9 View All» Clone: MFR5 (5H10-27) View All» Isotype: IgG2a View All» Background Information: CD49e is a member of a large integrin family of adhesion molecules. CD49e has been found to be involved in growth, motility, survival, cytoskeletal motility and control of gene expression. CD49e specifically is thought to be a receptor for fibronectin and, in some cell types, may play a part in growth and survival. Research has shown that with high levels of CD49e, tumor cell growth rates were diminished. It may also defend cells against apoptosis through mitogen deficiency. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: BALB/c thymus View All» Quality Assurance: Evaluated by Flow Cytometry in BALB/c thymus.Flow Cytometry Analysis: 1 µL of this antibody detected CD49e in BALB/c thymus. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P11688 View All» Entrez Gene Number: NP_034707 View All» Gene Symbol:

• ITGA5

• VLA-5

• CD49e

• VLA5A

• FNRA
  View All» Alternate Names:
  • integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

  • CD49 antigen-like family member E

  • fibronectin receptor, alpha subunit

  • Integrin alpha-F

  • very late activation protein 5, alpha subunit

  • Fibronectin receptor subunit alpha

  • integrin alpha-5

  • CD49e antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. May play a role in the survival of adult skeletal muscle.SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with NISCH. Interacts with HPS5 (By similarity). Interacts with RAB21 and COMP (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISRUPTION PHENOTYPE: Mice die at day E10-E11. They show both extraembryonic and embryonic vascular defects, and severe abnormalities in the development of the posterior trunk. SEQUENCE SIMILARITIES: Belongs to the integrin alpha chain family.Contains 7 FG-GAP repeats. View All» Product Name: Anti-Integrin alpha5 (CD49e), clone MFR5 (5H10-27) View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
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