货号：MABT24

品牌：Merck Millipore

规格：

目录价：￥3943.00

市场价格：￥3351.55

会员价格：￥3154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myomesin Antibody, clone 5D11 | MABT24 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes the C2 motifs 3-7 of Myomesin. View All» Molecular Weight: 188 kDa calculated MW View All» Epitope: C2 motifs 3-7 View All» Immunogen: Recombinant protein corresponding to the C2 motifs 3-7 of human Myomesin. View All» Clone: 5D11 View All» Isotype: IgMκ View All» Background Information: A fundamental structural component of the M-band, myomesin expression is observed in striated muscle of all kinds and found within many vertebrates. Myomesin’s primary function is considered to be the upkeep of the M-band filament lattice as it binds the titin-comprised elastic filament myosin. It also binds to titin and light meromyosin. Within the M-band, myomesin shares its structure with a closely related protein; the M-protein. Myomesin is expressed as several isoforms. The EH-myosin and H-myosin isoforms are of interest as markers for embryonic and adult specific cardiac muscle markers. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP, (Reddy, 2001). View All» Control: HeLa cells View All» Quality Assurance: Evaluated by Immunocytochemistry in HeLa cells.Immunocytochemistry Analysis: 1:500 dilution of this antibody detected Myomesin in HeLa cells. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P52179 View All» Entrez Gene Number: NP_003794 View All» Gene Symbol:

• MYOM1

• SKELEMIN
  View All» Alternate Names:
  • myomesin 1 (skekmin), 185kDa

  • EH-myomesin

  • skelemin

  • 190 kDa titin-associated protein

  • 190 kDa connectin-associated protein

  • myomesin (M-protein) 1 (190kD)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» Entrez Gene Summary: The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.SUBUNIT STRUCTURE: Interacts with TTN/titin by similarity. Interacts with PNKD. SEQUENCE SIMILARITIES: Contains 5 fibronectin type-III domains.Contains 5 Ig-like C2-type (immunoglobulin-like) domains.SEQUENCE CAUTION: The sequence CAA48833.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Myomesin, clone 5D11 View All» Concentration: 1.00 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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