货号：MABT381

品牌：Merck Millipore

规格：

目录价：￥3943.00

市场价格：￥3351.55

会员价格：￥3154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Alpha-Actin (smooth muscle) Antibody, clone EPR5368, Rabbit Monoclonal | MABT381 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of Alpha Actin. View All» Molecular Weight: ~42 kDa observed View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the N-terminus of human Alpha Actin. View All» Clone: EPR5368 View All» Background Information: Actins are highly conserved proteins ubiquitously expressed in all eukaryotic cells. They comprise, along with microtubules, a major component of the cytoskeleton. Actin has been found to be expressed in at least six isomeric forms. It is expressed in heart and skeletal striated muscle tissue, and in certain smooth muscle tissues, regulating contractile potentials for these cells. It is also expressed in the cytoplasm of non-muscle cells, functioning to control cell structure and motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin), whose formation requires the Arp2/3 complex. It has been reported that actin is hyperphosphorylated in primary breast tumors. It has also been shown that actin dysfunction leads to certain types of heart failure. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Furthermore, expression of smooth muscle alpha actin is regulated by hormones and cell proliferation, and is altered by pathological conditions including oncogenic transformation and atherosclerosis. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000-2,500 dilution from a representative lot was used to detect Alpha Actin in human ovary tissue.Immunocytochemistry Analysis: A 1:250-500 dilution from a representative lot was used in IC.Flow Cytometry Analysis: A 1:10-100 dilution from a representative lot was used in FC. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Immunohistochemistry on human heart tissue lysate.Immunohistochemistry Analysis: A 1:1,000-2,500 dilution of this antibody was used to detect Alpha Actin in human heart tissue. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P62736 View All» Entrez Gene Number: P62736 View All» Gene Symbol:
  • ACTSA

  • AAT6

  • OTTHUMP00000020042

  • ACTVS
    View All» Alternate Names:
    • actin, alpha 2, smooth muscle, aorta

    • Cell growth-inhibiting gene 46 protein

    • actin, aortic smooth muscle

    • alpha 2 actin

    • alpha-actin-2

    • alpha-cardiac actin

    • growth-inhibiting gene 46

    • Alpha-actin-2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry (Paraffin)

      • Immunocytochemistry

      • Flow Cytometry
        View All» Product Name: Anti-Alpha-Actin (smooth muscle), clone EPR5368, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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        © Merck Millipore代理MABT381 Anti-Alpha-Actin (smooth muscle), clone EPR5368, Rabbit Monoclonal，产品报价联系微信jinshanbio