货号：MABT39

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Laminin alpha 5 Antibody, clone 4B12 | MABT39 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 400 kDa calculated View All» Immunogen: Laminin purified from human placenta View All» Clone: 4B12 View All» Isotype: IgG1λ View All» Background Information: Laminin alpha 5 (α5) is a member of the laminin family of extracellular matrix glycoproteins. Laminin’s are important in cell migration, differentiation and in tumor cell incursion. Research shows that laminin alpha 5 may be an early marker of sexual differentiation. In rat, the laminin alpha 5 chain seems to halt expression in the basement membrane of Sertoli cells when secretion of AMH begins but expression increases two weeks after birth when AMH secretion stops. Laminin alpha 5 shows up early during lung development in mice. It has also been linked to inflammatory cell chemotaxis and metalloproteinase activity and may play a role in creating and sustaining mucosal patterns of the mouse small intestine. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Laminin alpha 5 in human blood vessels and metastatic colorectal adenocarcinoma tissues. View All» Control: Human precancerous colorectal lesion tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in human precancerous colorectal lesion tissue.Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Laminin alpha 5 in human precancerous colorectal lesion tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O15230 View All» Entrez Gene Number: NP_005551 View All» Gene Symbol: LAMA5 View All» Alternate Names:

• laminin, alpha 5

• Laminin-15 subunit alpha

• laminin alpha-5 chain

• Laminin-11 subunit alpha

• laminin subunit alpha-5

• Laminin-10 subunit alpha, Laminin α5, Lamininα5, Laminin-α5
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry View All» Entrez Gene Summary: Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.SUBUNIT STRUCTURE: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-5 is a subunit of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523).SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix › basement membrane. Note: Major component.TISSUE SPECIFICTY: Expressed in heart, lung, kidney, skeletal muscle, pancreas, retina and placenta. Little or no expression in brain and liver.DOMAIN: Domain G is globular and is part of the major cell-binding site located in the long arm of the laminin heterotrimer.SEQUENCE SIMILARITIES: Contains 22 laminin EGF-like domains.Contains 5 laminin G-like domains.Contains 1 laminin IV type A domain.Contains 1 laminin N-terminal domain.SEQUENCE CAUTION: The sequence CAC22310.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-Laminin alpha 5, clone 4B12 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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