货号：MABT394

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plakophilin-2 Antibody, clone 8H6 | MABT394 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~97 kDa observed View All» Immunogen: MBP-tagged recombinant protein corresponding to human Plakophilin-2. View All» Clone: 8H6 View All» Isotype: IgG1κ View All» Background Information: Plakophilin-2 (PKP2) is a member of the Armadillo/β-catenin family. It contains eight ARM repeats and can exist in two slice isoforms (2a and 2b). Plakophilin-2 is highly abundant in simple and stratified epithelial cells; but is also expressed in non-epithelial cells, such as the myocardium and lymph node follicles. In epithelial cells, it is localized to desmosomal plaques and plays an important role in cell-cell adhesion processes. Plakophilin-2 also maintains the cell-cell junctions of cardiac tissue, and is essential for proper cardiac function. Mutations in the plakophilin-2 gene cause arrhythmogenic right ventricular cardiomyopathy 9, a condition characterized by partial breakdown of the myocardium of the right ventricle, electrical instability, and sudden death. Plakophilin-2 has also been implicated in the development of cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in A431 and UM-SCC-38 cells. (Sobolik-Delmaire, T., et al. (2010). Journal of Investigative Dermatology. 130:2638–2646.) View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected Plakophilin-2 in 10 µg of A431 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q99959 View All» Entrez Gene Number: NP_004563 View All» Gene Symbol: PKP2 View All» Alternate Names: Plakophilin-2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Western Blotting

• Immunocytochemistry
  View All» Product Name: Anti-Plakophilin-2, clone 8H6 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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