货号：MABT44

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ICAM-3 (CD50) Antibody, clone CBR-IC3/1 | MABT44 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 59 kDa calculated View All» Immunogen: SKW3 cells View All» Clone: CBR-IC31 View All» Isotype: IgG1κ View All» Background Information: Intercellular adhesion molecule 3 (ICAM-3 or CD50) is a leukocyte differentiation antigen. ICAM-3 is thought to be important in the adhesion of the first stages of the immune response. ICAM-3 may also play a role in activating T lymphocytes. ICAM-3 is found in high levels on resting lymphocytes and is an important ligand for LFA-1. ICAM-3 is tyrosine phosphorylated and is associated with tyrosine kinase activity in human neutrophils. ICAM-3 may be the receptor glycoprotein that is the initial bacterial binding site for infective endocarditis by oral streptococci. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an indpendent laboratory in IP (de Fougerolles, A., et al. (1992). J. Exp. Med. 175:185-190).Western Blot Analysis: A previous lot was used by an indpendent laboratory in WB (de Fougerolles, A., et al. (1992). J. Exp. Med. 175:185-190). View All» Control: HL-60 cells View All» Quality Assurance: Evaluated by Flow Cytometry in HL-60 cells.Flow Cytometry Analysis: 1 µg of this antibody detected ICAM-3 (CD50) in HL-60 cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P32942 View All» Entrez Gene Number: NP_002153 View All» Gene Symbol:

• ICAM-3

• ICAM-R

• CDW50

• CD50

• CDw50
  View All» Alternate Names:
  • intercellular adhesion molecule 3

  • intercellular adhesion molecule-3

  • CD50 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily. ICAM family.Contains 5 Ig-like C2-type (immunoglobulin-like) domains. View All» Product Name: Anti-ICAM-3 (CD50), clone CBR-IC3/1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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