货号：MABT62

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nectin-2/PVRL2 (CD112) Antibody, clone R2.525 | MABT62 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 58 kDa calculated View All» Immunogen: NIH/3T3 cells transfected with human Nectin-2 View All» Clone: R2.525.2 View All» Isotype: IgG1κ View All» Background Information: Nectin-2 is also known as poliovirus receptor-related protein 2 (PRR2 or PVRL2) or CD112. Nectin-2 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. It is connected with the actin cytoskeleton through afadin inside the cell. Nectin-2 also seems to play an important part in shielding the heart against cardiac dysfunction in high pressure situations. Although Nectin-2 does not seem to be necessary under normal physiological circumstances, it acts autonomously of other adherens junction proteins. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human KG1a myeloid leukemia cells View All» Quality Assurance: Evaluated by Flow Cytometry in human KG1a myeloid leukemia cells.Flow Cytometry Analysis: 2.5 µg of this antibody detected Nectin-2/PVRL2 in human KG1a myeloid leukemia cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q92692 View All» Entrez Gene Number: NP_001036189 View All» Gene Symbol:

• PVRL2

• PRR2

• PVRR2

• HVEB

• CD112

• HveB
  View All» Alternate Names:
  • poliovirus receptor-related 2 (herpesvirus entry mediator B)

  • poliovirus receptor related 2

  • poliovirus receptor-related protein 2

  • herpesvirus entry protein B

  • poliovirus receptor-like 2

  • nectin-2

  • Herpes virus entry mediator B

  • CD112 antigen

  • Herpesvirus entry mediator B

  • Nectin-2

  • nectin 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Probable cell adhesion protein. SUBUNIT STRUCTURE: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Ubiquitous.SEQUENCE SIMILARITIES: Belongs to the nectin family.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-Nectin-2/PVRL2 (CD112), clone R2.525 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Purified View All» Host: Mouse View All»
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