货号：MABT66

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ILK Antibody, clone EP1593Y Rabbit | MABT66 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes ILK at the N-terminus. View All» Molecular Weight: ~ 51 kDa View All» Immunogen: Synthetic peptide corresponding to residues near the N-terminus of human ILK. View All» Clone: EP1593Y View All» Background Information: Integrin-linked kinase (ILK) is a key cytoplasmic plaque protein involved in the mediation of integrin functions. It plays a key role as a regulator during cell survival, cell proliferation, cell migration, and cell to cell adhesion (1). ILK links integrins to the actin cytoskeleton, allowing transduction of signals through integrins to the extracellular matrix (ECM). Also, ILK has been linked to the regulation of smooth contraction and cell motility in non-muscle cells through phosphorylation of myosin (2). Irregular activity level of ILK has been linked to expression of certain tumor. ILK overexpression caused by inactivating mutation in tumor suppressors (e.g. PTEN and APC) lead to tumor formation in transgenic mouse. Up-regulated ILK expression and activity are seen in Ewings scaromas, colorectal cancers, and late staged prostate cancers (3). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Proven to react with human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:50-100 dilution from a previous lot detected ILK in human heart muscle. View All» Control: COS cell lysate View All» Quality Assurance: Evaluated by Western Blot in COS cell lysate.Western Blot Analysis: 1:2,000-10,000 dilution of the antibody was used to detect ILK in COS lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl containing 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.05% BSA. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» UniProt Number: Q13418 View All» Entrez Gene Number: Q13418 View All» Gene Symbol:
  • ILK-1

  • ILK1

  • ILK-2

  • EC 2.7.11.1

  • ILK2
    View All» Alternate Names:
    • integrin-linked kinase

    • P59

    • DKFZp686F1765

    • 59 kDa serine/threonine-protein kinase

    • p59ILK
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Product Name: Anti-ILK, clone EP1593Y Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Unpurified View All» Host: Rabbit View All»
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