货号：MABT67

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-L-Selectin (CD62L) Antibody, Clone MEL-14 | MABT67 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 42 kDa calculated View All» Immunogen: 38C-13 B cell lymphoma cell lines derived from a C3H/eb mouse. View All» Clone: MEL-14 View All» Isotype: IgG2aκ View All» Background Information: L-selectin (CD62L) expression improves immune surveillance by encoding CD4+ T cell blood and lymph node spreading. Increased expression of CD62L has been linked to increased stress and certain panic disorders. It has been shown that CD4+ cells expressing CD62L can prevent the onset of diabetes. Subjects with cryptococcosis have been shown to have more soluble CD62L in the serum. The inability to get rid of CD62L may enhance leukocyte-mediated end-organ injury in patients with sepsis. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH (Reichert, R., et al. (1986). J Immunol. 136:3535-3542).Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Reichert, R., et al. (1986). J Immunol. 136:3535-3542). View All» Control: C57BL6 mouse splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in C57BL6 mouse splenocytes.Flow Cytometry Analysis: 2 µg of this antibody detected L-Selectin (CD62L) in C57BL6 mouse splenocytes. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P18337 View All» Entrez Gene Number: NP_035476 View All» Gene Symbol:

• LAM1

• LECAM1

• LNHR

• TQ1

• LYAM1

• gp90-MEL

• LSEL

• Leu-8

• PLNHR

• hLHRc

• CD62L

• LAM-1

• LEU8
  View All» Alternate Names:
  • selectin L

  • Leukocyte-endothelial cell adhesion molecule 1

  • CD62 antigen-like family member L

  • lymphocyte adhesion molecule 1

  • Lyam-1

  • Leukocyte adhesion molecule 1

  • pln homing receptor

  • Leukocyte surface antigen Leu-8

  • L-selectin

  • Lymph node homing receptor

  • CD62L antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry

    • Immunofluorescence
      View All» UniProt Summary: FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity). SUBUNIT STRUCTURE: Interaction with PSGL1/SELPLG is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan and tyrosine sulfation modifications of PSGL1. Probable sulfation on Y-54 of PSGL1 is most important for L-selectin binding.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Predominantly expressed in lymphoid tissue. SEQUENCE SIMILARITIES: Belongs to the selectin/LECAM family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 2 Sushi (CCP/SCR) domains. View All» Product Name: Anti-L-Selectin (CD62L), Clone MEL-14 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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