货号：MABT70

品牌：Merck Millipore

规格：100MIG

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD62L Antibody, clone LAMI-116 | MABT70 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 42 kDa calculated View All» Immunogen: Recombinant protein corresponding to human CD62L. View All» Clone: LAMI-116 View All» Isotype: IgG2aκ View All» Background Information: L-selectin (CD62L) expression improves immune surveillance by encoding CD4+ T cell blood and lymph node spreading. Increased expression of CD62L has been linked to increased stress and certain panic disorders. It has been shown that CD4+ cells expressing CD62L can prevent the onset of diabetes. Subjects with cryptococcosis have been shown to have more soluble CD62L in the serum. The inability to get rid of CD62L may enhance leukocyte-mediated end-organ injury in patients with sepsis. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Human PBMCs View All» Quality Assurance: Evaluated by Flow Cytometry in human PBMCs.Flow Cytometry Analysis: 0.5 µg of this antibody detected CD62L in human PBMCs. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P14151 View All» Entrez Gene Number: NP_000646 View All» Gene Symbol: SELL, LNHR, LYAM1 View All» Alternate Names:

• qp90-MEL

• TQ1

• CD62L

• TQ1

• LAM1

• LEU8

• LSEL

• CD62L

• PLNHR

• LECAM1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.SUBUNIT STRUCTURE: Interaction with PSGL1/SELPLG and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of PSGL1 and PODXL2, and tyrosine sulfation modifications of PSGL1. Sulfation on Y-51 of PSGL1 is important for L-selectin binding.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. View All» Product Name: Anti-CD62L, clone LAMI-116 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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